Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. - Test2 - elhamkhani - TriplyDB

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

http://www.wikidata.org/entity/Q30442183

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Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival Regulation of focal adhesion kinase by a novel protein inhibitor FIP200 The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion The docking protein HEF1 is an apoptotic mediator at focal adhesion sites Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals Characterization of palladin, a novel protein localized to stress fibers and cell adhesions.High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome.Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.Association of focal adhesion kinase with Grb7 and its role in cell migration Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells Cleavage of focal adhesion kinase by caspases during apoptosis The inhibition of p85αPI3KSer83 phosphorylation prevents cell proliferation and invasion in prostate cancer cells.Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein.Remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor.Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal.Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase.Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis.Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD.Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase Focal adhesion kinase and endothelial cell apoptosis.Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma.Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study.

P2860

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P2860

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

http://www.wikidata.org/entity/Q30442183

description

1996 nî lūn-bûn

@nan

1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1996年の論文

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1996年論文

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1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

name

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@ast

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@en

type

label

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@ast

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@en

prefLabel

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@ast

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@en

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Journal of Cell Biology

P1476

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

@en

P2093

B G Hoffstrom

http://www.w3.org/2001/XMLSchema#string

C A Otey

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J E Hungerford

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M L Matter

http://www.w3.org/2001/XMLSchema#string

M T Compton

http://www.w3.org/2001/XMLSchema#string

P2860

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

Disruption of epithelial cell-matrix interactions induces apoptosis

Signal transduction from the extracellular matrix

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

Integrins and signal transduction pathways: the road taken

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1383-1390

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10.1083/JCB.135.5.1383

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5

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135

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1996-12-01T00:00:00Z

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8947559

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2121083

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