Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.

Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.

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http://www.wikidata.org/entity/Q30454042
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersImaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorinContribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humansAvermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Oral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder.Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder.P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate NucleusRole of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.P2X4: A fast and sensitive purinergic receptor.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.
P2860

Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.

Item
http://www.wikidata.org/entity/Q30454042
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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