Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.

Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.

Item
http://www.wikidata.org/entity/Q30464012
Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome?A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity.Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling.Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-ouChemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity.Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.Transcuprein is a macroglobulin regulated by copper and iron availabilityInterleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production.Modification of mouse A2M B (620-792) and A2M N (168-230) by malondialdehyde and acetaldehyde attenuates the proteinase and TGF-β1 binding ability of A2MB.Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.The participation of nitric oxide in peritoneal exudate cell cytotoxicity of mice by Fusobacterium nucleatum.Tumor necrosis factor-alpha plus actinomycin D-induced apoptosis of L929 cells is prevented by nitric oxide.
P2860

Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.

Item
http://www.wikidata.org/entity/Q30464012
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@ast
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@en
type
label
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@ast
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@en
prefLabel
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@ast
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P356
P1433
P1476
Alpha 2-macroglobulin function ...... AW 264.7 macrophage cell line.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921