The presynaptic component of the serotonergic system is required for clozapine's efficacy. - Test2 - elhamkhani - TriplyDB

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

http://www.wikidata.org/entity/Q30471071

about

Preclinical models of antipsychotic drug action.Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function.Molecular genetics of mouse serotonin neurons across the lifespan.In Vitro and In Vivo Characterization of the Alkaloid Nuciferine Investigating the Role of Serotonin in Methamphetamine Psychosis: Unaltered Behavioral Effects of Chronic Methamphetamine in 5-HT1A Knockout Mice.Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype.Exploring the role of 5-HT1A receptors in the regulation of prepulse inhibition in mice: implications for cross-species comparisons.Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia.Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo.Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness.Balancing histone methylation activities in psychiatric disorders.Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi.Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knockout mice.Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins.Pain: novel analgesics from traditional Chinese medicines.Multitarget drug discovery projects in CNS diseases: quantitative systems pharmacology as a possible path forward.The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis.Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT(1A) Receptor-Dependent Mechanism.Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain.Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function.Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo.Opposite effects of typical and atypical anti-psychotic drugs on sensitized dopamine receptors: sub-chronic low dose Olanzapine exposure reverses sensitization but a similar regimen of low dose haloperidol potentiates sensitization effects.Residual dopamine receptor desensitization following either high- or low-dose sub-chronic prior exposure to the atypical anti-psychotic drug olanzapine.Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice.

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P2860

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

http://www.wikidata.org/entity/Q30471071

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The presynaptic component of t ...... ired for clozapine's efficacy.

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The presynaptic component of t ...... ired for clozapine's efficacy.

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The presynaptic component of t ...... ired for clozapine's efficacy.

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The presynaptic component of t ...... ired for clozapine's efficacy.

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Neuropsychopharmacology

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The presynaptic component of the serotonergic system is required for clozapine's efficacy

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Atheir I Abbas

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Brian K Shoichet

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Bryan L Roth

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David A Piel

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Evan S Deneris

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Martilias S Farrell

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Noah Sciaky

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Prem N Yadav

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Sheryl G Beck

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P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A beta-arrestin 2 signaling complex mediates lithium action on behavior

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

The protein kinase complement of the human genome

Common variants conferring risk of schizophrenia

Common variants on chromosome 6p22.1 are associated with schizophrenia

Predicting new molecular targets for known drugs

Large recurrent microdeletions associated with schizophrenia

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

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638-651

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10.1038/NPP.2010.195

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Michael J Keiser

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