Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids - Test2 - elhamkhani - TriplyDB

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

http://www.wikidata.org/entity/Q30491268

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Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis Immature B Cell Egress from Bone Marrow Is SOCS3 Independent What we know and do not know about the cannabinoid receptor 2 (CB2)T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung Two-photon microscopy analysis of leukocyte trafficking and motility.The location of splenic NKT cells favours their rapid activation by blood-borne antigen.Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.The bone marrow at the crossroads of blood and immunity Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.S1P1 receptor directs the release of immature B cells from bone marrow into blood.Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development.Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease Central B-cell tolerance: where selection begins.Endocannabinoid signalling in innate and adaptive immunity.Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization Perturbations of the endocannabinoid system in mantle cell lymphoma: correlations to clinical and pathological features.The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome.Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation.Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells.Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells Regulation of leucocyte homeostasis in the circulation.

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Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

http://www.wikidata.org/entity/Q30491268

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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Nature Immunology

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Jason G Cyster

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Jinping An

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João P Pereira

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Ying Xu

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Yong Huang

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P2860

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Intravascular large B-cell lymphoma. A report of five cases initially diagnosed by bone marrow biopsy.

Microenvironmental organization and stromal cell associations of B lymphocyte precursor cells in mouse bone marrow.

SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.

Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.

Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.

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19252491

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cannabinoid receptor

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2768754

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