Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer
about
The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its FunctionOptimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designingAtaxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIPMonitoring cotranslational protein folding in mammalian cells at codon resolutionA bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteinsIsoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogasterPrioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs.Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxiasUbiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencingDisrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
P2860
Q27661523-E1D2DC6A-1308-4844-B072-00BBA57A18A3Q28475117-C95C04A8-EBF3-44A1-A457-1DA0A4A41065Q30418755-438C54B4-098B-4457-8E2B-2BD585538253Q33353919-A1637A41-2354-462D-8A10-52A89DF0B931Q35152082-44E82266-D12A-4CDA-A6A4-DF21AD213779Q35542063-414038C6-8416-4149-800C-0727F8678F3FQ36517549-24516D1B-E07D-4DC6-AE45-25C1348FD545Q36604984-E977EBD9-6609-430C-BAF8-34C7FA8D65F9Q36671121-5D9A5A04-CFC2-4D4B-98B3-526BFB520D49Q37635847-581FA618-C9F4-4685-AFEC-C1B4117CE2CAQ58730541-806BD1C8-FDEE-47B4-A6E4-D4D4362EBD45
P2860
Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@ast
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@en
type
label
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@ast
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@en
prefLabel
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@ast
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@en
P2093
P2860
P356
P1476
Engineering a ubiquitin ligase ...... equired for ubiquitin transfer
@en
P2093
Cam Patterson
Lauren Waldron
Neelima Choudhary
Rachel E Klevit
Shu-Bing Qian
Walter J Chazin
P2860
P304
26797-26802
P356
10.1074/JBC.M109.032334
P407
P577
2009-07-31T00:00:00Z