Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. - Test2 - elhamkhani - TriplyDB

Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.

Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.

http://www.wikidata.org/entity/Q30495203

about

CD2 promotes human natural killer cell membrane nanotube formation LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy Cell biological steps and checkpoints in accessing NK cell cytotoxicity Cell polarisation and the immunological synapse Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules Human cytomegalovirus infection elicits new decidual natural killer cell effector functions.Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization.HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes.Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells Recognition of tumors by the innate immune system and natural killer cells.PTEN is a negative regulator of NK cell cytolytic function.A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants.HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.Human NK cell lytic granules and regulation of their exocytosis Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56 dim CD16+ and CD56 bright CD16 dim/- natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.Lysosome-related organelles: unusual compartments become mainstream.Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.Controlling natural killer cell responses: integration of signals for activation and inhibition.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.Molecular mechanisms of natural killer cell activation.Insights into NK cell biology from human genetics and disease associations.The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins.Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond Dynamics of NK cell interactions in vivo.New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.Activation of Lymphocyte Cytolytic Machinery: Where are We?Insights into primary immune deficiency from quantitative microscopy.Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry.Granule-Dependent Natural Killer Cell Cytotoxicity to Fungal Pathogens.NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.

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P2860

Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.

http://www.wikidata.org/entity/Q30495203

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Rapid lytic granule convergenc ...... but not cytolytic commitment.

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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type

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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MBC.E09-11-0930

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Molecular Biology of the Cell

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Rapid lytic granule convergenc ...... but not cytolytic commitment.

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P2093

Ashley N Mentlik

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Erika L Holzbaur

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Keri B Sanborn

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P2860

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3

Two activators of microtubule-based vesicle transport

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells

The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization

Dynactin increases the processivity of the cytoplasmic dynein motor

ER-to-Golgi transport visualized in living cells

Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution

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2241-2256

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scholarly article

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10.1091/MBC.E09-11-0930

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13

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21

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2010-05-05T00:00:00Z

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20444980

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2893988

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