Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer - Test2 - elhamkhani - TriplyDB

Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer

Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer

http://www.wikidata.org/entity/Q30497045

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The retinoid X receptors and their ligands Mass spectrometry coupled experiments and protein structure modeling methods.Localizing Carbohydrate Binding Sites in Proteins Using Hydrogen/Deuterium Exchange Mass Spectrometry.Integrating mass spectrometry of intact protein complexes into structural proteomics Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.Agonist and antagonist binding to the nuclear vitamin D receptor: dynamics, mutation effects and functional implications.Hydrogen-deuterium exchange and mass spectrometry reveal the pH-dependent conformational changes of diphtheria toxin T domain.DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Carboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase.Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.On-tissue Direct Monitoring of Global Hydrogen/Deuterium Exchange by MALDI Mass Spectrometry: Tissue Deuterium Exchange Mass Spectrometry (TDXMS).Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery H/D exchange centroid monitoring is insufficient to show differences in the behavior of protein states.Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation.Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.Mass spectrometric analysis of protein-ligand interactions.Understanding nuclear receptor form and function using structural biology Synthetic RORγt Agonists Enhance Protective Immunity.Hydrogen exchange mass spectrometry of functional membrane-bound chemotaxis receptor complexes HDX-MS guided drug discovery: small molecules and biopharmaceuticals.N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.Time window expansion for HDX analysis of an intrinsically disordered protein.Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1α,25-Dihydroxyvitamin D3 Signaling.Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.The conformational dynamics of H2-H3n and S2-H6 in gating ligand entry into the buried binding cavity of vitamin D receptor.High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.Calcipotriol induces autophagy in HeLa cells and keratinocytes.Regulation of the vitamin D receptor by vitamin D lactam derivatives.The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).

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Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer

http://www.wikidata.org/entity/Q30497045

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

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J.STR.2010.07.007

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Hydrogen/deuterium exchange re ...... etinoid X receptor heterodimer

@en

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Bruce D Pascal

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Jeffery A Dodge

http://www.w3.org/2001/XMLSchema#string

Jun Zhang

http://www.w3.org/2001/XMLSchema#string

Keith R Stayrook

http://www.w3.org/2001/XMLSchema#string

Lorri L Burris

http://www.w3.org/2001/XMLSchema#string

Michael J Chalmers

http://www.w3.org/2001/XMLSchema#string

Patrick R Griffin

http://www.w3.org/2001/XMLSchema#string

Ruben D Garcia-Ordonez

http://www.w3.org/2001/XMLSchema#string

Thomas P Burris

http://www.w3.org/2001/XMLSchema#string

P2860

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

Noncalcemic Actions of Vitamin D Receptor Ligands

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation

Partial agonists activate PPARgamma using a helix 12 independent mechanism

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

The steroid and thyroid hormone receptor superfamily

Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

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1332-1341

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scholarly article

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10.1016/J.STR.2010.07.007

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10

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18

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20947021

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