about
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionAdjuvant-enhanced antibody responses in the absence of toll-like receptor signalingCentral role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gutEfficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathwayHerpes simplex virus encephalitis in human UNC-93B deficiencyThe Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosisIdentification of Lps2 as a key transducer of MyD88-independent TIR signallingA toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteriaThe interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingCD36 is a sensor of diacylglyceridesATF3 is a novel regulator of mouse neutrophil migrationGenetic analysis of host resistance: Toll-like receptor signaling and immunity at large.Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.STAT5 is critical to maintain effector CD8+ T cell responses.ENU-induced phenovariance in mice: inferences from 587 mutations.Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.How we detect microbes and respond to them: the Toll-like receptors and their transducers.Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.Hepatic (dys-)function during inflammation.Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses.Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins.Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses.NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.The interface between innate and adaptive immunity.Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses.A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis.Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.An ENU mutagenesis approach to dissect "self"-induced immune responses: Unraveling the genetic footprint of immunosurveillance.Genetic analysis of innate immunity.TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy.Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.Dissecting innate immunity by germline mutagenesis.Forward genetic analysis of TLR-signaling pathways: an evaluation.
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
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հետազոտող
@hy
name
Kasper Hoebe
@ast
Kasper Hoebe
@en
Kasper Hoebe
@es
Kasper Hoebe
@fr
Kasper Hoebe
@nl
Kasper Hoebe
@sl
type
label
Kasper Hoebe
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Kasper Hoebe
@en
Kasper Hoebe
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Kasper Hoebe
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Kasper Hoebe
@nl
Kasper Hoebe
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prefLabel
Kasper Hoebe
@ast
Kasper Hoebe
@en
Kasper Hoebe
@es
Kasper Hoebe
@fr
Kasper Hoebe
@nl
Kasper Hoebe
@sl
P106
P1153
6603967096
P21
P31
P496
0000-0002-3626-8098