High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells. - Test2 - elhamkhani - TriplyDB

High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.

High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.

http://www.wikidata.org/entity/Q30530234

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The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay Decoding Polo-like kinase 1 signaling along the kinetochore-centromere axis Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation Impact of Polo-like kinase 1 inhibitors on human adipose tissue-derived mesenchymal stem cells.Polo-like kinases: structural variations lead to multiple functions.Understanding the Polo Kinase machine.Genotoxicity assessment of two common curing weeds: Hyptis suaveolens (L.) Poir. and Leucas indica (L.) R. Br.Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1).Scytonemin inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in multiple myeloma cells.Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies.Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis.Gravin regulates centrosome function through PLK1.Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.Re-investigating PLK1 inhibitors as antimitotic agents.Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma.Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis.A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key

P2860

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P2860

High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.

http://www.wikidata.org/entity/Q30530234

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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High mitotic activity of Polo- ...... ity in human epithelial cells.

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High mitotic activity of Polo- ...... ity in human epithelial cells.

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High mitotic activity of Polo- ...... ity in human epithelial cells.

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High mitotic activity of Polo- ...... ity in human epithelial cells.

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JBC.M112.412544

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Journal of Biological Chemistry

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High mitotic activity of Polo- ...... ity in human epithelial cells.

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Mark E Burkard

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Robert F Lera

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P2860

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells

NIH Image to ImageJ: 25 years of image analysis

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

Polo-like kinase controls vertebrate spindle elongation and cytokinesis

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

The chromosomal passenger complex activates Polo kinase at centromeres

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42812-42825

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10.1074/JBC.M112.412544

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51

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287

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