Protein biophysics explains why highly abundant proteins evolve slowly
about
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsComparing protein folding in vitro and in vivo: foldability meets the fitness challengeLoss of quaternary structure is associated with rapid sequence divergence in the OSBS familyA model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolutionEvolutionary dynamics of Rh2 opsins in birds demonstrate an episode of accelerated evolution in the New World warblers (Setophaga)Roles of solvent accessibility and gene expression in modeling protein sequence evolutionBiophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Interplay between chaperones and protein disorder promotes the evolution of protein networks.Biophysics of protein evolution and evolutionary protein biophysicsEvolutionary biochemistry: revealing the historical and physical causes of protein properties.The influence of selection for protein stability on dN/dS estimationsPositively selected sites in cetacean myoglobins contribute to protein stability.Protein folding and binding can emerge as evolutionary spandrels through structural coupling.Proteome folding kinetics is limited by protein halflife.Depletion of cells and abundant proteins from biological samples by enhanced dielectrophoresis.Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.Contribution of selection for protein folding stability in shaping the patterns of polymorphisms in coding regions.Conserved proteins are fragile.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution.Intermediate divergence levels maximize the strength of structure-sequence correlations in enzymes and viral proteins.Evolutionary dynamics of viral escape under antibodies stress: A biophysical model.Catalysis of protein folding by chaperones accelerates evolutionary dynamics in adapting cell populationsSequence-Based Analysis of Thermal Adaptation and Protein Energy Landscapes in an Invasive Blue Mussel (Mytilus galloprovincialis).Thermophilic adaptation in prokaryotes is constrained by metabolic costs of proteostasis.Highly abundant proteins favor more stable 3D structures in yeast.Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli.Fitness costs of minimal sequence alterations causing protein instability and toxicity.Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes.Avoidance of toxic misfolding and protein stability do not explain the sequence constraints of highly expressed proteins.Accelerated simulation of evolutionary trajectories in origin-fixation models.Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Refining the Ambush Hypothesis: Evidence That GC- and AT-Rich Bacteria Employ Different Frameshift Defence Strategies.Protein evolution speed depends on its stability and abundance and on chaperone concentrations
P2860
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P2860
Protein biophysics explains why highly abundant proteins evolve slowly
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Protein biophysics explains why highly abundant proteins evolve slowly
@ast
Protein biophysics explains why highly abundant proteins evolve slowly
@en
type
label
Protein biophysics explains why highly abundant proteins evolve slowly
@ast
Protein biophysics explains why highly abundant proteins evolve slowly
@en
prefLabel
Protein biophysics explains why highly abundant proteins evolve slowly
@ast
Protein biophysics explains why highly abundant proteins evolve slowly
@en
P2860
P1433
P1476
Protein biophysics explains why highly abundant proteins evolve slowly
@en
P2093
Zilvinas Rimas
P2860
P304
P356
10.1016/J.CELREP.2012.06.022
P577
2012-08-02T00:00:00Z