Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis - Test2 - elhamkhani - TriplyDB

Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis

Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis

http://www.wikidata.org/entity/Q30536784

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Invadopodia in context Regulation of ECM degradation and axon guidance by growth cone invadosomes.Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces Phosphoinositide 3-kinase p85beta regulates invadopodium formation.FAK competes for Src to promote migration against invasion in melanoma cells.The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo.5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells.Regulation of invadopodia by the tumor microenvironment.Invadopodia and basement membrane invasion in vivo.The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer.ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines.PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.Signaling inputs to invadopodia and podosomes Mechanotransduction at focal adhesions: from physiology to cancer development.Invadopodia, regulation, and assembly in cancer cell invasion.MS/MS-based strategies for proteomic profiling of invasive cell structures.Phosphatidylinositolphosphate phosphatase activities and cancer.A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.SHIP2: Structure, Function and Inhibition.Cell adhesion and invasion mechanisms that guide developing axons Exosome secretion is enhanced by invadopodia and drives invasive behavior.Force-dependent breaching of the basement membrane.5-Azacytidine promotes invadopodia formation and tumor metastasis through the upregulation of PI3K in ovarian cancer cells.Cell invasion through basement membrane: The netrin receptor DCC guides the way.Automated analysis of invadopodia dynamics in live cells.Cdc42 and Tks5: a minimal and universal molecular signature for functional invadosomes.Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer.Platelet-Derived Growth Factor Receptor Activation Promotes the Prodestructive Invadosome-Forming Phenotype of Synoviocytes from Patients with Rheumatoid Arthritis.miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation

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Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis

http://www.wikidata.org/entity/Q30536784

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2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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Network analysis of the focal ...... K-PKCα invasive signaling axis

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Network analysis of the focal ...... K-PKCα invasive signaling axis

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Network analysis of the focal ...... K-PKCα invasive signaling axis

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Network analysis of the focal ...... K-PKCα invasive signaling axis

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Science Signaling

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Network analysis of the focal ...... K-PKCα invasive signaling axis

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Bing Zhang

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Brandee Brown

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Daisuke Hoshino

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Darren R Tyson

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Gordon B Mills

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Jerome Jourquin

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Kaitlin Costello

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Margalit Goldgof

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Motoharu Seiki

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Nagendra K Prasad

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The Hallmarks of Cancer

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading

Cytoscape: a software environment for integrated models of biomolecular interaction networks

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

Formation of regulatory patterns during signal propagation in a Mammalian cellular network

Supervised clustering of genes

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Integrins in mechanotransduction

Invadopodia: specialized cell structures for cancer invasion

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110

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241

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5

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Alissa M. Weaver

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2012-09-11T00:00:00Z

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230833561

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3583194

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