Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. - Test2 - elhamkhani - TriplyDB

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

http://www.wikidata.org/entity/Q30554446

about

Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Centrosome - a promising anti-cancer target Models in biology: lessons from modeling regulation of the eukaryotic cell cycle Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II Entry into mitosis: a solution to the decades-long enigma of MPF α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes Mastl kinase, a promising therapeutic target, promotes cancer recurrence.MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.Regulation of Greatwall kinase by protein stabilization and nuclear localization Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice.Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism.Ensa controls S-phase length by modulating Treslin levels.Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit.Regulation of Cell Division.Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.Spatial Separation of Plk1 Phosphorylation and Activity.Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast.Coupling TOR to the Cell Cycle by the Greatwall-Endosulfine-PP2A-B55 Pathway.Role of Greatwall kinase in release of mouse oocytes from diplotene arrest.Regulating Greatwall for mitosis.Mastl/PP2A regulate Cdk1 in ooycte maturation.Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.Cell cycle-dependent regulation of Greatwall kinase by protein phosphatase 1 and regulatory subunit 3B.Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.MAST-like protein kinase IREH1 from Arabidopsis thaliana co-localizes with the centrosome when expressed in animal cells.MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes.Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis.Identification of new inhibitors against human Great wall kinase using in silico approaches.Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry.

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P2860

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

http://www.wikidata.org/entity/Q30554446

description

2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

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2013年論文

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2013年論文

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2013年论文

@wuu

name

Greatwall is essential to prev ...... envelope breakdown in mammals.

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Greatwall is essential to prev ...... envelope breakdown in mammals.

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type

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Greatwall is essential to prev ...... envelope breakdown in mammals.

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Greatwall is essential to prev ...... envelope breakdown in mammals.

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Greatwall is essential to prev ...... envelope breakdown in mammals.

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Greatwall is essential to prev ...... envelope breakdown in mammals.

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PNAS.1310745110

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Proceedings of the National Academy of Sciences of the United States of America

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Greatwall is essential to prev ...... envelope breakdown in mammals.

@en

P2093

Anna Castro

http://www.w3.org/2001/XMLSchema#string

Belén Sanz-Castillo

http://www.w3.org/2001/XMLSchema#string

María Sanz-Flores

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Miguel Ruiz-Torres

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Pei Pei Gan

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Ruth Sánchez-Martínez

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Thierry Lorca

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P2860

MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

The overlooked greatwall: a new perspective on mitotic control

Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase

PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos

Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis

Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

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scholarly article

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10.1073/PNAS.1310745110

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43

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110

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Marcos Malumbres

Marianna Trakala

Mónica Alvarez

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2013-10-07T00:00:00Z

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257531334

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24101512

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