Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.

Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.

Item
http://www.wikidata.org/entity/Q30570720
Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screensX-ray structure of the pestivirus NS3 helicase and its conformation in solution.Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor.B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin componentsDesigning inhibitors of anthrax toxinSystematic discovery of molecular probes targeting multiple non-orthosteric and spatially distinct sites in the botulinum neurotoxin subtype A (BoNT/A).Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs.Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.Use of allosteric targets in the discovery of safer drugs.Exploiting computationally derived out-of-the-box protein conformations for drug design.Ab initio sampling of transition paths by conditioned Langevin dynamics.Does bromodomain flexibility influence histone recognition?
P2860

Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.

Item
http://www.wikidata.org/entity/Q30570720
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
@ast
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
@en
type
label
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
@ast
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
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prefLabel
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
@ast
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
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P1433
P1476
P2093
P275
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932
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P1433
P1476
Molecular motions as a drug ta ...... f novel allosteric inhibitors.
@en
P2093
P275
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932