Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening - Test2 - elhamkhani - TriplyDB

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

http://www.wikidata.org/entity/Q30577535

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Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.Pharmacological Correctors of Mutant CFTR Mistrafficking.Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.Phenotype-optimized sequence ensembles substantially improve prediction of disease-causing mutation in cystic fibrosis.Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.Molecular modelling and molecular dynamics of CFTR.A novel approach to recovery of function of mutant proteins by slowing down translation.Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.Unravelling druggable signalling networks that control F508del-CFTR proteostasis CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Mechanism-based corrector combination restores ΔF508-CFTR folding and function.Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.Functional Rescue of F508del-CFTR Using Small Molecule Correctors Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Cystic fibrosis transmembrane regulator correctors and potentiators.Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Matrine modulates HSC70 levels and rescues ΔF508-CFTR.Benzbromarone stabilizes ΔF508 CFTR at the cell surface.Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.Fixing cystic fibrosis by correcting CFTR domain assembly.Strategies for the etiological therapy of cystic fibrosis.SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule.Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR.Molecular basis of cystic fibrosis: from bench to bedside

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

http://www.wikidata.org/entity/Q30577535

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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type

label

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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prefLabel

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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S10822-010-9390-0

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Journal of Computer - Aided Molecular Design

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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P2093

Alina Shitrit

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Diana R Wetmore

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Efrat Ben-Zeev

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Hanoch Senderowitz

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Hermann Bihler

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Martin Mense

http://www.w3.org/2001/XMLSchema#string

Nili Schutz

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Ori Kalid

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Philip J Thomas

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Robert J Bridges

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P2860

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Development and validation of a genetic algorithm for flexible docking

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

Structure of a bacterial multidrug ABC transporter

Novel procedure for modeling ligand/receptor induced fit effects.

Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

How does consensus scoring work for virtual library screening? An idealized computer experiment.

PREDICT modeling and in-silico screening for G-protein coupled receptors.

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.

Correctors of protein trafficking defects identified by a novel high-throughput screening assay.

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s10822-010-9390-0

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971-991

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10.1007/S10822-010-9390-0

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12

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24

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Nicoletta Pedemonte

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2010-10-26T00:00:00Z

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47545910

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20976528

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4010227

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