Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
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Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysisSmall-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathologyStructure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctorsEnhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.Pharmacological Correctors of Mutant CFTR Mistrafficking.Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitorsDiscovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.Phenotype-optimized sequence ensembles substantially improve prediction of disease-causing mutation in cystic fibrosis.Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.Molecular modelling and molecular dynamics of CFTR.A novel approach to recovery of function of mutant proteins by slowing down translation.Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.Unravelling druggable signalling networks that control F508del-CFTR proteostasisCFTR: folding, misfolding and correcting the ΔF508 conformational defect.Mechanism-based corrector combination restores ΔF508-CFTR folding and function.Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.Functional Rescue of F508del-CFTR Using Small Molecule CorrectorsRepairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Cystic fibrosis transmembrane regulator correctors and potentiators.Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Matrine modulates HSC70 levels and rescues ΔF508-CFTR.Benzbromarone stabilizes ΔF508 CFTR at the cell surface.Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.Fixing cystic fibrosis by correcting CFTR domain assembly.Strategies for the etiological therapy of cystic fibrosis.SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule.Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR.Molecular basis of cystic fibrosis: from bench to bedside
P2860
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P2860
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
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2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@ast
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@en
type
label
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@ast
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@en
prefLabel
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@ast
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@en
P2093
P2860
P1476
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
@en
P2093
Alina Shitrit
Diana R Wetmore
Efrat Ben-Zeev
Hanoch Senderowitz
Hermann Bihler
Martin Mense
Nili Schutz
Philip J Thomas
Robert J Bridges
P2860
P2888
P304
P356
10.1007/S10822-010-9390-0
P577
2010-10-26T00:00:00Z