Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. - Test2 - elhamkhani - TriplyDB

Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.

Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.

http://www.wikidata.org/entity/Q30725634

about

PPARs and the cardiovascular system PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding Fibrates, glitazones, and peroxisome proliferator-activated receptors Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins Role of Peroxisome Proliferator-Activated Receptor (PPAR)δ in Embryonic Stem Cell Proliferation.Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.The peroxisome proliferator-activated receptor β/δ agonist GW0742 has direct protective effects on right heart hypertrophy.The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.Differential sensitivities of the vascular K(ATP) channel to various PPAR activators Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ.Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate.Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells.Generation and characterization of a humanized PPARδ mouse model Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.Metabolic Functions of Peroxisome Proliferator-Activated Receptor beta/delta in Skeletal Muscle.ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases.Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling.The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

P2860

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P2860

Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.

http://www.wikidata.org/entity/Q30725634

description

2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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name

Novel selective small molecule ...... hesis and biological activity.

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Novel selective small molecule ...... hesis and biological activity.

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type

label

Novel selective small molecule ...... hesis and biological activity.

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Novel selective small molecule ...... hesis and biological activity.

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prefLabel

Novel selective small molecule ...... hesis and biological activity.

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Novel selective small molecule ...... hesis and biological activity.

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Bioorganic & Medicinal Chemistry Letters

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Novel selective small molecule ...... hesis and biological activity.

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P2093

Adam Fivush

http://www.w3.org/2001/XMLSchema#string

Christelle LeGrumelec

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Curt D Haffner

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Daniel D Sternbach

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Donna Goreham

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Esther Chao

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H Eric Xu

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Marcos L Sznaidman

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Michael L Sierra

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Millard H Lambert

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1517-1521

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scholarly article

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10.1016/S0960-894X(03)00207-5

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9

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12699745

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