Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
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Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodiesSequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41Efficient recovery of high-affinity antibodies from a single-chain Fab yeast display library.Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutAffinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1Characteristics of the earliest cross-neutralizing antibody response to HIV-1.Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralizationBinding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformationsPhages and HIV-1: from display to interplay.Designing a soluble near full-length HIV-1 gp41 trimer.Increased functional stability and homogeneity of viral envelope spikes through directed evolution.Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum.Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virionsDesign and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheetReceptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.Neutralizing antibodies to HIV-1 induced by immunization.Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins.From rabbit antibody repertoires to rabbit monoclonal antibodiesRole of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region.Novel neutralising antibodies targeting the N-terminal helical region of the transmembrane envelope protein p15E of the porcine endogenous retrovirus (PERV).HIV Entry and Its Inhibition by Bifunctional Antiviral ProteinsDisplay of the HIV envelope protein at the yeast cell surface for immunogen development
P2860
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P2860
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Antibody elicited against the ...... ies also bind to NHR mimetics.
@ast
Antibody elicited against the ...... ies also bind to NHR mimetics.
@en
type
label
Antibody elicited against the ...... ies also bind to NHR mimetics.
@ast
Antibody elicited against the ...... ies also bind to NHR mimetics.
@en
prefLabel
Antibody elicited against the ...... ies also bind to NHR mimetics.
@ast
Antibody elicited against the ...... ies also bind to NHR mimetics.
@en
P2093
P2860
P1433
P1476
Antibody elicited against the ...... dies also bind to NHR mimetics
@en
P2093
Carole A Bewley
Dan Leaman
Dennis R Burton
Douglas D Richman
Florence M Brunel
Heather Kinkead
John M Louis
Josh D Nelson
Katherine Bowdish
Michael B Zwick
P2860
P304
P356
10.1016/J.VIROL.2008.04.005
P407
P577
2008-05-21T00:00:00Z