Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. - Test2 - elhamkhani - TriplyDB

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

http://www.wikidata.org/entity/Q30843874

about

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41 Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41 Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41 Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41 Efficient recovery of high-affinity antibodies from a single-chain Fab yeast display library.Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neut Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41 SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1 Characteristics of the earliest cross-neutralizing antibody response to HIV-1.Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations Phages and HIV-1: from display to interplay.Designing a soluble near full-length HIV-1 gp41 trimer.Increased functional stability and homogeneity of viral envelope spikes through directed evolution.Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum.Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1 Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.Neutralizing antibodies to HIV-1 induced by immunization.Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins.From rabbit antibody repertoires to rabbit monoclonal antibodies Role of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region.Novel neutralising antibodies targeting the N-terminal helical region of the transmembrane envelope protein p15E of the porcine endogenous retrovirus (PERV).HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins Display of the HIV envelope protein at the yeast cell surface for immunogen development

P2860

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P2860

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

http://www.wikidata.org/entity/Q30843874

description

2008 nî lūn-bûn

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2008年の論文

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Carole A Bewley

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Dan Leaman

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Dennis R Burton

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Douglas D Richman

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Florence M Brunel

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Katherine Bowdish

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P2860

Cryo-electron tomographic structure of an immunodeficiency virus envelope complex in situ

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Potent D-peptide inhibitors of HIV-1 entry

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

Core structure of gp41 from the HIV envelope glycoprotein

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1

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G. Marius Clore

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5351375

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2493441

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