The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder.
about
Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy backgroundCognate peptide-receptor ligand mapping by directed phage display.Human leukocyte Antigen-DM polymorphisms in autoimmune diseasesStructure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetesExploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinityGenetics of type 1 diabetes mellitusNatural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithmsNew design of MHC class II tetramers to accommodate fundamental principles of antigen presentationTargeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.I-Ag7 is subject to post-translational chaperoning by CLIP.On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.Mapping I-A(g7) restricted epitopes in murine G6PC2.Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD miceExpression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathyThymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competitionUse of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetesRegister shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletionSusceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.Genetic lesions in T-cell tolerance and thresholds for autoimmunity.Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transferDo the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?Accelerated turnover of MHC class II molecules in nonobese diabetic mice is developmentally and environmentally regulated in vivo and dispensable for autoimmunity.MHC Class II Protein Turnover In vivo and Its Relevance for Autoimmunity in Non-Obese Diabetic Mice.Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.Structural alterations in peptide-MHC recognition by self-reactive T cell receptors.Prevention of type 1 diabetes by gene therapy.In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.Structural basis for self-recognition by autoimmune T-cell receptors.The structural basis of HLA-associated drug hypersensitivity syndromes.Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity.Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptidePeptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices.Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells.Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cells
P2860
Q24273412-B0C2A681-49ED-404F-8360-47FCBF5EA374Q24811166-D37FF225-481F-4DCF-8BBE-8CC13AF7D601Q26741035-190B3C17-064A-4EE2-9EFF-BC205B5B90CBQ27632133-B052E107-FB12-4245-B023-A9B8DF881E5DQ27641946-18102C90-7B4A-4773-BEB7-9DEB1622F64FQ27660688-01E987E3-52C4-4606-A156-28C11401E5A5Q28215982-8E70385A-F015-4F6A-8CC8-FC1F7D77B68BQ33220897-A828C1B6-BD1C-4424-BDA9-2576DD9A4213Q33306761-51CB1B57-0785-4551-8763-D01813A23343Q33348203-C88BA4D5-0CC2-43B7-B76C-BC70B09B356CQ33755350-4B67ADAD-63F7-45BF-8F75-B1DB4F1205B6Q33934705-F5F375A4-62A6-458A-8FB9-C57B75CA0AA1Q34013568-70A44AFD-9A88-454C-99B0-9F3E9FFD0D9DQ34150236-6CD96A7D-6973-4823-B438-462199103137Q34415712-D0196FFB-0F88-400F-B12C-C92E484AB918Q34527126-483BE29A-2110-41DB-87F6-7B5DF2B378E2Q34600485-F53735E2-59DA-4AB4-9289-D0337B8B998EQ34876029-7F663466-F08A-44C0-B1A1-76BE3BCB0312Q34982899-05A55918-38C0-4221-8012-4207E7E02E74Q35651667-4069CA86-5BB4-4ABF-A56D-318648553C6AQ35669113-8981C3DF-F886-428B-9CD9-E8C095136C4CQ35919777-61B32F78-2316-4414-B74B-7F52C63E2303Q36079868-D7B1888E-BED8-4F3B-9799-632AF82ECDDDQ36370946-F19F886B-BD7E-4351-94C3-B1813A3F0DD1Q36376604-992A83B4-810D-4B2A-BA43-0F5976F81385Q37033008-5BCF8B65-D218-4284-AEEE-F7C39D9471FCQ37202316-FECC7DBB-4F1E-4C8D-9AD1-F02246881BE1Q37338924-4F5A6505-1104-4E4B-A699-8129E3293A01Q37376821-34853002-0AE2-4453-89D9-1C2BBB9CC8E8Q37456210-F574A6F0-00C3-4E7A-AB9D-77B98224C119Q37532745-7D560E85-5C41-46A3-9D86-CCA1877E0D1CQ37714655-C2ABF493-3DB4-438E-9F4A-2CF28B902D00Q38050478-D0BA4DD1-CCB0-4563-9129-A020574E51BCQ38050483-4313B364-0ED4-4285-AD9C-3C0F01E0960DQ38135862-EC9443FB-CFEF-495F-8F1B-F4002CB81FC6Q38153381-F3A786F6-9F04-4627-838D-03EECD4AC811Q39912767-199CA6BD-1F2B-4354-AF29-F3E3C474DDCAQ40240283-87ECFFF4-C3BB-4166-B748-B3D267283DACQ40316222-49E9DC46-E215-4B14-B535-D443AD070C83Q41772561-BDC42613-3F05-415B-9B08-3F97D931493E
P2860
The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@ast
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@en
type
label
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@ast
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@en
prefLabel
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@ast
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@en
P2093
P1476
The I-Ag7 MHC class II molecul ...... a promiscuous peptide binder.
@en
P2093
Apostolopoulos V
Mallet-Designe V
Stratmann T
P304
P356
10.4049/JIMMUNOL.165.6.3214
P407
P577
2000-09-01T00:00:00Z