Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli.
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A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhACombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilRapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial useFitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparumOrigin of robustness in generating drug-resistant malaria parasitesConflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelCrystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.Chemotherapeutic hope on the horizon for Plasmodium vivax malaria?Compensatory mutations restore fitness during the evolution of dihydrofolate reductaseEvaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Folate metabolism as a source of molecular targets for antimalarials.Drug-resistant malaria - an insight.High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo.Stepwise acquisition of pyrimethamine resistance in the malaria parasiteThe evolutionary landscape of antifolate resistance in Plasmodium falciparum.Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.
P2860
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P2860
Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Novel antifolate resistant mut ...... selected in Escherichia coli.
@ast
Novel antifolate resistant mut ...... selected in Escherichia coli.
@en
type
label
Novel antifolate resistant mut ...... selected in Escherichia coli.
@ast
Novel antifolate resistant mut ...... selected in Escherichia coli.
@en
prefLabel
Novel antifolate resistant mut ...... selected in Escherichia coli.
@ast
Novel antifolate resistant mut ...... selected in Escherichia coli.
@en
P2093
P1476
Novel antifolate resistant mut ...... selected in Escherichia coli.
@en
P2093
Bongkoch Tarnchompoo
Pornpan Thiensathit
Sudsanguan Chusacultanachai
Worachart Sirawaraporn
Yongyuth Yuthavong
P356
10.1016/S0166-6851(01)00440-6
P577
2002-03-01T00:00:00Z