Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
about
Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine LeiomyomataLuteolin, a flavonoid with potential for cancer prevention and therapyChinese Herbs Interfering with Cancer Reprogramming MetabolismLipidome in colorectal cancerA novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosisCrystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo- -linolenic acidLOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cellsLipid metabolism emerges as a promising target for malignant glioma therapy.Feasibility and antitumor efficacy in vivo, of simultaneously targeting glycolysis, glutaminolysis and fatty acid synthesis using lonidamine, 6-diazo-5-oxo-L-norleucine and orlistat in colon cancer.Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infectionLipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicityWest Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipidsInhibition of fatty acid metabolism reduces human myeloma cells proliferation.Bacterial viability and physical properties of antibacterially modified experimental dental resin composites.Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Expression of Lipid Metabolism-Related Proteins in Metastatic Breast CancerMetformin: multi-faceted protection against cancer.Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells.The synergy and mode of action of quercetin plus amoxicillin against amoxicillin-resistant Staphylococcus epidermidis.Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs.Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine.Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cellsTranscriptional control of cellular metabolism by mTOR signaling.Cellular fatty acid metabolism and cancerThe metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.Anti-carcinogenic effects of the flavonoid luteolin.Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis.Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthaseSuppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells.Emerging roles of lipid metabolism in cancer metastasis.MR evaluation of response to targeted treatment in cancer cells.The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming.The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.
P2860
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P2860
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Pharmacological inhibitors of ...... family of anti-cancer agents?
@ast
Pharmacological inhibitors of ...... family of anti-cancer agents?
@en
type
label
Pharmacological inhibitors of ...... family of anti-cancer agents?
@ast
Pharmacological inhibitors of ...... family of anti-cancer agents?
@en
prefLabel
Pharmacological inhibitors of ...... family of anti-cancer agents?
@ast
Pharmacological inhibitors of ...... family of anti-cancer agents?
@en
P1476
Pharmacological inhibitors of ...... family of anti-cancer agents?
@en
P2093
Javier A Menendez
P304
P356
10.2174/138920106779116928
P577
2006-12-01T00:00:00Z