New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
about
Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallographySimilar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesteraseHuprines as a new family of dual acting trypanocidal-antiplasmodial agentsUndifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxideInteraction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.Targeting acetylcholinesterase to treat neurodegeneration.Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect.Cholinesterase inhibitors: a patent review (2007 - 2011).Huprines for Alzheimer's disease drug development.New insights into the kinetic target-guided synthesis of protein ligands.Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.The investigation of structure-activity relationships of tacrine analogues: electronic-topological method.Classical molecular interaction potentials: improved setup procedure in molecular dynamics simulations of proteins.Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).Cholinesterase inhibitors from the roots of Harpagophytum procumbens.Reaction site-driven regioselective synthesis of AChE inhibitors.Genoprotective and neuroprotective effects of Daphne gnidium leaf methanol extract, tested on male mice.Molecular dynamics, flexible docking, virtual screening, ADMET predictions, and molecular interaction field studies to design novel potential MAO-B inhibitors.Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.Modeling of acetylcholinesterase inhibition by tacrine analogues using Bayesian-regularized Genetic Neural Networks and ensemble averaging.
P2860
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P2860
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@ast
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@en
type
label
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@ast
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@en
prefLabel
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@ast
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@en
P2093
P356
P1476
New tacrine-huperzine A hybrid ...... atment of Alzheimer's disease.
@en
P2093
D Muñoz-Torrero
El Achab R
P304
P356
10.1021/JM000980Y
P407
P577
2000-11-01T00:00:00Z