Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
about
Structural basis for potency differences between GDF8 and GDF11.The impact of structural biology in medicine illustrated with four case studies.Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Domagrozumab (PF-06252616), an Antimyostatin Monoclonal Antibody, in Healthy Subjects.A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolguMyostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice.Local and global anatomy of antibody-protein antigen recognition.Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.Blocking extracellular activation of myostatin as a strategy for treating muscle wasting.Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy.
P2860
Q31813087-D9FBE4A9-80D3-49DE-ABCA-7EC8A73A72EBQ38698199-DC5B165C-7FD5-436A-9B26-16E0C9294766Q40062515-9982E207-2DCB-4A9D-9014-B7F0FF102E89Q47127942-840F46A1-2996-4ECD-821E-3113571B13FDQ47205244-F0524648-7001-4693-80F5-E4948F9CF51EQ47316363-07FB9EFF-752E-43DB-9EB8-C0D1D1D14791Q48224207-822B3B2A-28C1-42D4-B75B-7B5DA6EE32A1Q48514411-2A026DBA-E346-468B-973C-54467B7CEDD0Q49592680-8CB73FDC-BE43-4354-B6DC-F9B8F83B51AF
P2860
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@ast
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@en
type
label
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@ast
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@en
prefLabel
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@ast
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@en
P2093
P2860
P921
P1476
Beyond CDR-grafting: Structure ...... of an anti-myostatin antibody.
@en
P2093
Carl Morris
James R Apgar
Jane Owens
Kevin Parris
Kris Svenson
Lioudmila Tchistiakova
Mark Johnson
Mark Krebs
Michael St Andre
Michelle Mader
P2860
P304
P356
10.1080/19420862.2016.1215786
P577
2016-09-13T00:00:00Z