In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies.
about
Intraspecies prion transmission results in selection of sheep scrapie strains.Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies.Loss of prion protein induces a primed state of type I interferon-responsive genes.Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc))Glycosylphosphatidylinositol anchor-dependent stimulation pathway required for generation of baculovirus-derived recombinant scrapie prion protein.Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.Cellular prion protein and caveolin-1 interaction in a neuronal cell line precedes Fyn/Erk 1/2 signal transduction.Characterization of Syrian hamster adapted prions derived from L-type and C-type bovine spongiform encephalopathiesMicroglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strainsBovine spongiform encephalopathy in Japan: history and recent studies on oxidative stress in prion diseases.Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.Isolation of two distinct prion strains from a scrapie-affected sheep.Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases.Prion protein and susceptibility to kainate-induced seizures: genetic pitfalls in the use of PrP knockout mice.Physiological Functions of the Cellular Prion Protein.Characterization and application of a novel RNA aptamer against the mouse prion protein.Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP.Copper binding to the PrP isoforms: a putative marker of their conformation and function.Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel.Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.Fusion of Doppel to octapeptide repeat and N-terminal half of hydrophobic region of prion protein confers resistance to serum deprivation.Human anti-prion antibodies block prion peptide fibril formation and neurotoxicity.Prion protein lacks robust cytoprotective activity in cultured cells.Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form.Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress.Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration.Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.Two different scrapie prions isolated in Japanese sheep flocks.An ancient conserved role for prion protein in learning and memory.In situ detection of cellular and abnormal isoforms of prion protein in brains of cattle with bovine spongiform encephalopathy and sheep with scrapie by use of a histoblot technique.A de novo designed template for generating conformation-specific antibodies that recognize alpha-helices in proteins.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.
P2860
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P2860
In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
In vivo conversion of cellular ...... formation-specific antibodies.
@ast
In vivo conversion of cellular ...... formation-specific antibodies.
@en
type
label
In vivo conversion of cellular ...... formation-specific antibodies.
@ast
In vivo conversion of cellular ...... formation-specific antibodies.
@en
prefLabel
In vivo conversion of cellular ...... formation-specific antibodies.
@ast
In vivo conversion of cellular ...... formation-specific antibodies.
@en
P2093
P2860
P356
P1476
In vivo conversion of cellular ...... formation-specific antibodies.
@en
P2093
Nakashiba T
Yokoyama T
P2860
P304
11265-11271
P356
10.1074/JBC.M008734200
P407
P577
2001-01-10T00:00:00Z