The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
about
Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsDNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosisEquivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.ATP-noncompetitive CDK inhibitors for cancer therapy: an overview.Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.Neuronal differentiation by analogs of staurosporine.
P2860
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P2860
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@ast
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@en
type
label
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@ast
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@en
prefLabel
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@ast
The broad-range cyclin-depende ...... ssion of the Bcl-x(L) protein.
@en
P2093
P2860
P356
P1433
P1476
The broad-range cyclin-depende ...... ession of the Bcl-x(L) protein
@en
P2093
Antje Müller
Christoph Hanski
Edward A Sausville
Kimitoshi Kohno
Mandar R Bhonde
Marie-Luise Hanski
Martin Zeitz
Peter T Daniel
Peter Wiegand
Roberta Magrini
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207842
P407
P577
2005-01-01T00:00:00Z
P5875
P6179
1007682831