Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
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Targeting Hsp90 in urothelial carcinomaLoss of a 20S proteasome activator in Saccharomyces cerevisiae downregulates genes important for genomic integrity, increases DNA damage, and selectively sensitizes cells to agents with diverse mechanisms of actionAn RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogasterSystematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 InteractionDevelopment and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.Chemogenomics approaches to novel target discovery.High-content image-based screening for small-molecule chaperone amplifiers in heat shock.Small molecule DnaK modulators targeting the beta-domain.Identification of inhibitors of HSF1 functional activity by high-content target-based screening.KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoterProteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70Heat shock protein 70 (hsp70) as an emerging drug target.Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cellsAnti-malaria drug blocks proteotoxic stress response: anti-cancer implications.Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.Withaferin A targets heat shock protein 90 in pancreatic cancer cells.Heat shock proteins in breast cancer progression--a suitable case for treatment?NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuRHsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugsMolecular chaperones in mammary cancer growth and breast tumor therapyRole of membrane Hsp70 in radiation sensitivity of tumor cellsHSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein.Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesisInduction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitizationHeat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.Transcription of Satellite III non-coding RNAs is a general stress response in human cellsA database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancerInhibitors of the heat shock response: biology and pharmacology.A systematic study of the features critical for designing a high avidity multivalent aptamer.Implication of heat shock factors in tumorigenesis: therapeutical potential.Targeting the oncogene and kinome chaperone CDC37.Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activityHsp70 in cancer: back to the future.Anti-Transcription Factor RNA Aptamers as Potential Therapeutics.An RNA aptamer that interferes with the DNA binding of the HSF transcription activator.When Cancer Fights Back: Multiple Myeloma, Proteasome Inhibition, and the Heat-Shock Response.Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells.
P2860
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P2860
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@ast
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@en
type
label
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@ast
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@en
prefLabel
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@ast
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@en
P2093
P1433
P1476
Targeting heat shock response ...... oteasome and Hsp90 inhibitors.
@en
P2093
John A Porco
Nava Zaarur
Stuart Calderwood
P304
P356
10.1158/0008-5472.CAN-05-3692
P407
P577
2006-02-01T00:00:00Z