Mining and engineering natural-product biosynthetic pathways.
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Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide HydrolaseTowards prediction of metabolic products of polyketide synthases: an in silico analysisDrug discovery prospect from untapped species: indications from approved natural product drugsMining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerizationWhole cell biocatalysts: essential workers from Nature to the industry.Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells.Importance of microbial natural products and the need to revitalize their discovery.In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteinsCloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clustersChapter 23. Cyanobactin ribosomally synthesized peptides--a case of deep metagenome miningExploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discoveryStructural mass spectrometry: rapid methods for separation and analysis of peptide natural productsThoughts and facts about antibiotics: where we are now and where we are heading.Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery.Genomic basis for natural product biosynthetic diversity in the actinomycetesBioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection.Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria.Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation.Novel tryptophan metabolism by a potential gene cluster that is widely distributed among actinomycetes.Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca.Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuseOpportunities for enzyme engineering in natural product biosynthesis.Mushroom hunting by using bioinformatics: application of a predictive framework facilitates the selective identification of sesquiterpene synthases in basidiomycotaRibosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis.Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces.Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.Natural products for cancer chemotherapy.Metabolic engineering is key to a sustainable chemical industry.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Biodiscovery from rare actinomycetes: an eco-taxonomical perspective.The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.Anaerobic bacteria as producers of antibiotics.
P2860
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P2860
Mining and engineering natural-product biosynthetic pathways.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Mining and engineering natural-product biosynthetic pathways.
@ast
Mining and engineering natural-product biosynthetic pathways.
@en
Mining and engineering natural-product biosynthetic pathways.
@nl
type
label
Mining and engineering natural-product biosynthetic pathways.
@ast
Mining and engineering natural-product biosynthetic pathways.
@en
Mining and engineering natural-product biosynthetic pathways.
@nl
prefLabel
Mining and engineering natural-product biosynthetic pathways.
@ast
Mining and engineering natural-product biosynthetic pathways.
@en
Mining and engineering natural-product biosynthetic pathways.
@nl
P356
P1476
Mining and engineering natural-product biosynthetic pathways.
@en
P2093
Barrie Wilkinson
Jason Micklefield
P2860
P2888
P304
P356
10.1038/NCHEMBIO.2007.7
P577
2007-07-01T00:00:00Z
P5875
P6179
1048719834