Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. - Test2 - elhamkhani - TriplyDB

Sterile protection against malaria is independent of immune responses to the circumsporozoite protein.

Sterile protection against malaria is independent of immune responses to the circumsporozoite protein.

http://www.wikidata.org/entity/Q33312392

about

Reflections on early malaria vaccine studies, the first successful human malaria vaccination, and beyond Malaria parasite pre-erythrocytic stage infection: gliding and hiding Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites Malaria vaccines: where next?A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites.Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites Identification of pre-erythrocytic malaria antigens that target hepatocytes for killing in vivo and contribute to protection elicited by whole-parasite vaccination.Antigen export during liver infection of the malaria parasite augments protective immunity Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory.Advances and challenges in malaria vaccine development.Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites.Plasmodium immunomics.A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes Antibody and B cell responses to Plasmodium sporozoites.Memory B-cell and antibody responses induced by Plasmodium falciparum sporozoite immunization.Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity The case for a rational genome-based vaccine against malaria.Malaria and the liver: immunological hide-and-seek or subversion of immunity from within?Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates.Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice A Sporozoite- and Liver Stage-expressed Tryptophan-rich Protein Plays an Auxiliary Role in Plasmodium Liver Stage Development and Is a Potential Vaccine Candidate.Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine Progress with viral vectored malaria vaccines: A multi-stage approach involving "unnatural immunity".Pre-erythrocytic malaria vaccines: identifying the targets.Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites.A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein.The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice.Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses Purification of Plasmodium Sporozoites Enhances Parasite-Specific CD8+ T Cell Responses.

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P2860

Sterile protection against malaria is independent of immune responses to the circumsporozoite protein.

http://www.wikidata.org/entity/Q33312392

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2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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P2860

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei

A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses

Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity

Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.

The Plasmodium sporozoite survives RTS,S vaccination.

Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.

Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine.

Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial.

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Andrea Crisanti

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