The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. - Test2 - elhamkhani - TriplyDB

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

http://www.wikidata.org/entity/Q33325927

about

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering Virological and cellular roles of the transcriptional coactivator LEDGF/p75 Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity HIV Genome-Wide Protein Associations: a Review of 30 Years of Research Impact of Chromatin on HIV Replication The Road Less Traveled: HIV's Use of Alternative Routes through Cellular Pathways Structural basis for functional tetramerization of lentiviral integrase Functional and structural characterization of the integrase from the prototype foamy virus A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.Retrotransposons. An RNA polymerase III subunit determines sites of retrotransposon integration.Retroviral Integrase: Then and Now LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.Novel approaches to inhibiting HIV-1 replication.AAV's anatomy: roadmap for optimizing vectors for translational success Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide element Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.Resistance to integrase inhibitors.Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types.Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors.Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.Retroviral integrase proteins and HIV-1 DNA integration Retroviral Integrase Structure and DNA Recombination Mechanism Lentiviral vector integration profiles differ in rodent postmitotic tissues

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P2860

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

http://www.wikidata.org/entity/Q33325927

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@ast

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@en

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

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type

label

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@ast

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@en

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@nl

prefLabel

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

@ast

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

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Alan Engelman

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Peter Cherepanov

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Creative Commons Attribution 4.0 International

P2860

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus

Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

HIV-1 integrase crosslinked oligomers are active in vitro

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

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