A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. - Test2 - elhamkhani - TriplyDB

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

http://www.wikidata.org/entity/Q33333429

about

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management Mechanism of cancer cell death induced by depletion of an essential replication regulator Crystal structure of human CDC7 kinase in complex with its activator DBF4 Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195 A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.Regulation and roles of Cdc7 kinase under replication stress.A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe Chk1 promotes replication fork progression by controlling replication initiation.CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor R-loop-mediated genomic instability is caused by impairment of replication fork progression Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1 Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo.Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis Kinase inhibitors as potential agents in the treatment of multiple myeloma.DNA replication licensing control and rereplication prevention.Genetic variation and DNA replication timing, or why is there late replicating DNA?Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme.Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.Molecular architecture of the DNA replication origin activation checkpoint.

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P2860

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

http://www.wikidata.org/entity/Q33333429

description

2008 nî lūn-bûn

@nan

2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@ast

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@en

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@nl

type

label

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@ast

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@en

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@nl

prefLabel

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@ast

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@en

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@nl

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P1433

Nature Chemical Biology

P1476

A Cdc7 kinase inhibitor restri ...... on and has antitumor activity.

@en

P2093

Aaron Bensimon

http://www.w3.org/2001/XMLSchema#string

Alessia Montagnoli

http://www.w3.org/2001/XMLSchema#string

Antonella Ciavolella

http://www.w3.org/2001/XMLSchema#string

Antonella Isacchi

http://www.w3.org/2001/XMLSchema#string

Antonio Molinari

http://www.w3.org/2001/XMLSchema#string

Barbara Valsasina

http://www.w3.org/2001/XMLSchema#string

Clara Albanese

http://www.w3.org/2001/XMLSchema#string

Daniele Volpi

http://www.w3.org/2001/XMLSchema#string

Dario Ballinari

http://www.w3.org/2001/XMLSchema#string

Deborah Brotherton

http://www.w3.org/2001/XMLSchema#string

P2860

A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

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P304

357-365

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scholarly article

P356

10.1038/NCHEMBIO.90

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P433

6

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P478

4

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Corrado Santocanale

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2008-05-11T00:00:00Z

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P698

18469809

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