Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons. - Test2 - elhamkhani - TriplyDB

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons.

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons.

http://www.wikidata.org/entity/Q33340515

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Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector PEGylated Adenoviruses: From Mice to Monkeys Gene therapy: light is finally in the tunnel Coagulation factor X activates innate immunity to human species C adenovirus Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile.Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model.Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors.Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.Adenoviral vector immunity: its implications and circumvention strategies.Peptide-based technologies to alter adenoviral vector tropism: ways and means for systemic treatment of cancer Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus.Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy.Pre-existing immunity and passive immunity to adenovirus 5 prevents toxicity caused by an oncolytic adenovirus vector in the Syrian hamster model Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue.Bioengineered factor IX molecules with increased catalytic activity improve the therapeutic index of gene therapy vectors for hemophilia B MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus.Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.Replicating rather than nonreplicating adenovirus-human immunodeficiency virus recombinant vaccines are better at eliciting potent cellular immunity and priming high-titer antibodies.Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad.Recognition of virus infection and innate host responses to viral gene therapy vectors.Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons.Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species Current strategies and future directions for eluding adenoviral vector immunity Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.Species differences in the pharmacology and toxicology of PEGylated helper-dependent adenovirus Helper-dependent adenoviral vectors for liver-directed gene therapy.IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells Gene therapy progress and prospects: adenoviral vectors.Virus infection recognition and early innate responses to non-enveloped viral vectors.Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector.Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)Ad3-hTERT-E1A, a fully serotype 3 oncolytic adenovirus, in patients with chemotherapy refractory cancer.Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques.

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P2860

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons.

http://www.wikidata.org/entity/Q33340515

description

2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年论文

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Lethal toxicity, severe endoth ...... adenoviral vector in baboons.

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Human Gene Therapy

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Lethal toxicity, severe endoth ...... adenoviral vector in baboons.

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Arthur L Beaudet

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Claire Langston

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Estuardo Aguilar-Córdova

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Karen Rice

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M Michelle Leland

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