Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer - Test2 - elhamkhani - TriplyDB

Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

http://www.wikidata.org/entity/Q33340988

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Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer The emerging role of GATA transcription factors in development and disease Pathology and molecular genetics of pancreatic neoplasms.An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6.Molecular signatures of pancreatic cancer.GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.SMURF1 amplification promotes invasiveness in pancreatic cancer.Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.GATA Transcription Factors and Cancer.Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas.miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis.GATA factors in endocrine neoplasia Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival.Gene-expression profiling in pancreatic cancer.GATA factors in gastrointestinal malignancy.EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.Lineage factors and differentiation states in lung cancer progression.A tumor profile in Edwards syndrome (trisomy 18).The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.Silencing of GATA6 suppresses SW1990 pancreatic cancer cell growth in vitro and up-regulates reactive oxygen species.Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation.ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines.Genome profiling of pancreatic adenocarcinoma.GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.19q13 amplification is associated with high grade and stage in pancreatic cancer.A 25-gene classifier predicts overall survival in resectable pancreatic cancer.Ca2+/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation.Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.

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Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

http://www.wikidata.org/entity/Q33340988

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2008 nî lūn-bûn

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Genomic profiling identifies G ...... ied in pancreatobiliary cancer

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Collins A Karikari

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Craig P Giacomini

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Edumakanti C Reddy

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Gowrishankar Swarnalata

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Jessica Kao

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Kelli Montgomery

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Pei Wang

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P2860

A family of human receptors structurally related to Drosophila Toll

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Significance analysis of microarrays applied to the ionizing radiation response

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

Characterizing the cancer genome in lung adenocarcinoma.

The human genome browser at UCSC

MATCH: A tool for searching transcription factor binding sites in DNA sequences

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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Matt van de Rijn

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