A Phase I study of CHS 828 in patients with solid tumor malignancy.

A Phase I study of CHS 828 in patients with solid tumor malignancy.

Item
http://www.wikidata.org/entity/Q33344280
New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncologyStructural basis for resistance to diverse classes of NAMPT inhibitorsStructure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drugNicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartmentsDependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells.Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy.Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes.Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment.
P2860

A Phase I study of CHS 828 in patients with solid tumor malignancy.

Item
http://www.wikidata.org/entity/Q33344280
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2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
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2002年學術文章
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name
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@ast
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@en
type
label
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@ast
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@en
prefLabel
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@ast
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@en
P1433
P1476
P2093
P304
P31
P407
P433
P478
P50
P577
P698
P1433
P1476
A Phase I study of CHS 828 in patients with solid tumor malignancy.
@en
P2093
P304
P31
P407
P433
P478
P50
P577
P698