Development of selective agonists and antagonists of P2Y receptors. - Test2 - elhamkhani - TriplyDB

Development of selective agonists and antagonists of P2Y receptors.

Development of selective agonists and antagonists of P2Y receptors.

http://www.wikidata.org/entity/Q33348980

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Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.Bovine Polymorphonuclear Neutrophils Cast Neutrophil Extracellular Traps against the Abortive Parasite Neospora caninum.Activation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells.Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.Involvement of UTP in protection of cardiomyocytes from hypoxic stress.Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation.Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.Thymidine 5'-O-monophosphorothioate induces HeLa cell migration by activation of the P2Y6 receptor.Predominant role of spinal P2Y1 receptors in the development of neuropathic pain in rats.Lack of specificity shown by P2Y6 receptor antibodies.Discovery of Potential Orthosteric and Allosteric Antagonists of P2Y1R from Chinese Herbs by Molecular Simulation Methods.Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries.P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.Nucleotides regulate secretion of the inflammatory chemokine CCL2 from human macrophages and monocytes.Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold.Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.Purine receptors and Ca(2+) signalling in the human blood-brain barrier endothelial cell line hCMEC/D3 ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal carcinoma cells.Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors.UTP - Gated Signaling Pathways of 5-HT Release from BON Cells as a Model of Human Enterochromaffin Cells.Development of a comprehensive set of P2 receptor pharmacological research compounds P2Y2 receptor antagonists as anti-allodynic agents in acute and sub-chronic trigeminal sensitization: role of satellite glial cells.Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia.UDP-sugars activate P2Y14 receptors to mediate vasoconstriction of the porcine coronary artery.ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages.Purinergic modulation of norepinephrine release and uptake in rat brain cortex: contribution of glial cells.Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.The two faces of pannexins: new roles in inflammation and repair.P2Y2R-mediated inflammasome activation is involved in tumor progression in breast cancer cells and in radiotherapy-resistant breast cancer

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P2860

Development of selective agonists and antagonists of P2Y receptors.

http://www.wikidata.org/entity/Q33348980

description

2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Development of selective agonists and antagonists of P2Y receptors.

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Development of selective agonists and antagonists of P2Y receptors.

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type

label

Development of selective agonists and antagonists of P2Y receptors.

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Development of selective agonists and antagonists of P2Y receptors.

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prefLabel

Development of selective agonists and antagonists of P2Y receptors.

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Development of selective agonists and antagonists of P2Y receptors.

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Purinergic Signalling

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Development of selective agonists and antagonists of P2Y receptors.

@en

P2093

Andrei A Ivanov

http://www.w3.org/2001/XMLSchema#string

Hyojin Ko

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T Kendall Harden

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P2860

Identification of the platelet ADP receptor targeted by antithrombotic drugs

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy

Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase

Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

P2-pyrimidinergic receptors and their ligands

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

Identification of a novel human ADP receptor coupled to G(i)

A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models

Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes

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75-89

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10.1007/S11302-008-9106-2

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1

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Kenneth A. Jacobson

Sonia de Castro

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2721770

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