Roles of protease-activated receptors in a mouse model of endotoxemia. - Test2 - elhamkhani - TriplyDB

Roles of protease-activated receptors in a mouse model of endotoxemia.

Roles of protease-activated receptors in a mouse model of endotoxemia.

http://www.wikidata.org/entity/Q33370039

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Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation.Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice.The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals.Differential signaling by protease-activated receptors: implications for therapeutic targeting.FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression.A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome.Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis.Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction.Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia.Protease-activated receptor-2 augments experimental crescentic glomerulonephritis Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response.Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans New paradigms in sepsis: from prevention to protection of failing microcirculation.Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells Tissue factor as an initiator of coagulation and inflammation in the lung.A role for thrombin in the initiation of the immune response to therapeutic factor VIII.Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis.Systemic versus localized coagulation activation contributing to organ failure in critically ill patients.Coagulation cascade proteinases in lung injury and fibrosis.Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.Suppression of peripheral sympathetic activity underlies protease-activated receptor 2-mediated hypotension Endothelial injury in sepsis.Endothelial protein C receptor: location...with a pool!Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.Evaluation of the host response to endotoxemia of FVIII and FIX deficient mice.The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity.

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Roles of protease-activated receptors in a mouse model of endotoxemia.

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Roles of protease-activated receptors in a mouse model of endotoxemia.

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Roles of protease-activated receptors in a mouse model of endotoxemia.

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Cathepsin G activates protease-activated receptor-4 in human platelets

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

Protease-activated receptor 3 is a second thrombin receptor in humans

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

PARticipation in inflammation

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Science review: role of coagulation protease cascades in sepsis

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