The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.
about
Linkage between the mechanisms of thrombocytopenia and thrombopoiesisTranscription factors in late megakaryopoiesis and related platelet disordersPluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical applicationStructure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphologyThe secret life of a megakaryocyte: emerging roles in bone marrow homeostasis controlWhole-genome analysis informs breast cancer response to aromatase inhibitionBone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesisWorldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in AfricaLoss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activationMegakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and lamininMutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability.Platelet formationRegulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiencyMYH-9 Related Platelet Disorders: Strategies for Management and DiagnosisRecent advances in the understanding and management of MYH9-related inherited thrombocytopenias.May-Hegglin anomaly in a dog.Inherited platelet disorders: a clinical approach to diagnosis and management.Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.Does size matter in platelet production?Inherited thrombocytopenias: an approach to diagnosis and management.Genetics of familial forms of thrombocytopenia.Inherited thrombocytopenias frequently diagnosed in adults.Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Lessons in platelet production from inherited thrombocytopenias.Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopeniaRituximab induced psoriasis in an infant.Molecular basis of inherited thrombocytopenias.Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan.Inherited thrombocytopenias-recent advances in clinical and molecular aspects.Life without double-headed non-muscle myosin II motor proteins.The incredible journey: From megakaryocyte development to platelet formation.Microtubule and cortical forces determine platelet size during vascular platelet production.The role of vertebrate nonmuscle Myosin II in development and human disease.
P2860
Q26770863-7B94B43A-61B3-4805-8300-C0D7D9F27439Q27015841-413BEE67-7E7A-41F5-915B-6AC9F1C90DDCQ27026899-BADB7B9C-4322-4B40-BACB-061387F05BABQ27680926-9843EDF3-D8F0-4561-944C-54838C28F47BQ28082685-ED67BD0A-DFDA-407D-90D8-7C53F9F6F4B1Q28269291-25F14035-34A8-44B6-90DA-2E85B253A388Q28472310-3743ED50-033F-4905-B58B-36800AA6D2E5Q28750412-CF0F7563-3DBB-4196-9E03-3E9466F6F1E5Q30481021-13189F87-1542-4BB3-8C24-F4FAB95BF58BQ30502470-590E0143-F9D6-47AD-9EE0-EB134BEBD448Q30528487-BA615059-B2FD-49C2-B2AA-0B3DA9F17730Q30536225-6A266AAD-B0B7-4264-B104-72CCDC42AD48Q30583557-817336F5-77F2-403E-AFA7-F17FD75CA332Q30840174-EF58CCD5-FFAF-4825-A8EB-79348E53AA8CQ31059222-F2F2002D-B012-4609-A6CC-FA326B49DA9DQ31127014-9F8AC7EB-8F84-4694-9A07-5A3BD95A8DC9Q33390619-B8A6E14F-E0B4-4671-8C06-1C634CBDA825Q33392062-669E9BE0-51AF-4081-A6A0-75861DC6CDC7Q33393007-76D0F178-EB4A-4D50-83ED-DCFF68E4C41AQ33395195-8BAF6D4E-787F-49F7-8C20-9D6FBCB8676EQ33395233-9442EE80-1852-4F3B-8893-830A21D0A78DQ33396427-BA696607-A26D-41C9-A65D-942E12559083Q33397121-6065E04D-C7A4-4E3A-9201-AB10AD173558Q33401595-E7697230-FD61-433B-BF5B-B8FB928DBE1EQ33402583-9755D481-F97D-4EB3-A52E-D97715513086Q33402780-709CDC53-CD80-401C-86E9-851DC9196514Q33406532-E5B6CBB3-F139-4AC8-A5AC-05F8FFAAAE9AQ33407443-39F406EB-BC0A-4644-A3CE-1197932EBC49Q33411165-DB7B687B-BBDA-4290-AC29-E9561D9B5B41Q33413048-0BB3E335-DA29-43A3-96F5-5CED5E451C6FQ33414742-62559B1C-7B0A-4BBF-8B12-E40CD59196B4Q33418701-143943E5-58E8-42BF-86BC-EDD85B63CA57Q33418857-5AC75D6C-53AC-4068-8CE9-B51FCF8DE2F1Q33422658-AF8504A2-5B28-4938-B283-904872176644Q33431116-9A084912-EC1D-40CA-BE0C-205D4EBCF1FFQ33432109-629CDA41-CB4C-4DAD-A76E-9EEE649E97D8Q33852054-821C5B68-3E68-4B50-A8C9-BC4DC4151460Q34037117-D209E186-EDAF-4E18-8B86-3C86BF56618AQ34278424-8044EFD4-484F-4CAD-8F90-745019C1D8CDQ34362453-BC637D52-CF81-4680-B767-8C9A2C9D48DC
P2860
The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@ast
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@en
type
label
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@ast
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@en
altLabel
The May-Hegglin anomaly gene M ...... ulated by the Rho-ROCK pathway
@en
prefLabel
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@ast
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@en
P2093
P2860
P50
P1433
P1476
The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.
@en
P2093
Mary Anne Conti
Ramesh A Shivdasani
P2860
P304
P356
10.1182/BLOOD-2007-02-071589
P407
P577
2007-03-28T00:00:00Z