The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. - Test2 - elhamkhani - TriplyDB

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.

http://www.wikidata.org/entity/Q33374705

about

Linkage between the mechanisms of thrombocytopenia and thrombopoiesis Transcription factors in late megakaryopoiesis and related platelet disorders Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control Whole-genome analysis informs breast cancer response to aromatase inhibition Bone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesis Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability.Platelet formation Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency MYH-9 Related Platelet Disorders: Strategies for Management and Diagnosis Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias.May-Hegglin anomaly in a dog.Inherited platelet disorders: a clinical approach to diagnosis and management.Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.Does size matter in platelet production?Inherited thrombocytopenias: an approach to diagnosis and management.Genetics of familial forms of thrombocytopenia.Inherited thrombocytopenias frequently diagnosed in adults.Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Lessons in platelet production from inherited thrombocytopenias.Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia Rituximab induced psoriasis in an infant.Molecular basis of inherited thrombocytopenias.Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan.Inherited thrombocytopenias-recent advances in clinical and molecular aspects.Life without double-headed non-muscle myosin II motor proteins.The incredible journey: From megakaryocyte development to platelet formation.Microtubule and cortical forces determine platelet size during vascular platelet production.The role of vertebrate nonmuscle Myosin II in development and human disease.

P2860

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P2860

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.

http://www.wikidata.org/entity/Q33374705

description

2007 nî lūn-bûn

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.

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The May-Hegglin anomaly gene M ...... lated by the Rho-ROCK pathway.

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Mary Anne Conti

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Ramesh A Shivdasani

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Zhao Chen

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P2860

Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

Microinjection of recombinant p21rho induces rapid changes in cell morphology

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains

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1

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Robert S. Adelstein

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Alessandra Balduini

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2007-03-28T00:00:00Z

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6416717

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17392504

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1896110

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