Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells.
about
Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumabA foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomersDetecting morphologically distinct oligomeric forms of alpha-synuclein.Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chainsNovel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody librariesConstruction of human Fab library and screening of a single-domain antibody of amyloid-beta 42 oligomers.Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples.Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.Isolation and characterization of antibody fragments selective for toxic oligomeric tauStructure-based design of conformation- and sequence-specific antibodies against amyloid β.CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease.Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice.Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity.TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseasesDeveloping intrabodies for the therapeutic suppression of neurodegenerative pathology.Progress in the development of therapeutic antibodies targeting prion proteins and beta-amyloid peptides.Preclinical to phase II amyloid beta (Aβ) peptide modulators under investigation for Alzheimer's disease.Recombinant Antibody Fragments for Neurodegenerative Diseases.An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway.Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations.A sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples.Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis.Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathwaysPolyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β.Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation.APP/Aβ structural diversity and Alzheimer's disease pathogenesis.A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.Methods for the Specific Detection and Quantitation of Amyloid-β Oligomers in Cerebrospinal Fluid.Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.CNS disease-related protein variants as blood-based biomarkers in traumatic brain injuryMagnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
P2860
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P2860
Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@ast
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@en
type
label
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@ast
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@en
prefLabel
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@ast
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@en
P2093
P1476
Anti-oligomeric Abeta single-c ...... nst human neuroblastoma cells.
@en
P2093
Andleeb Zameer
Michael R Sierks
Sharareh Emadi
Sridevi V Nimmagadda
Srinath Kasturirangan
P304
P356
10.1016/J.JMB.2008.09.068
P407
P577
2008-10-07T00:00:00Z