Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. - Test2 - elhamkhani - TriplyDB

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

http://www.wikidata.org/entity/Q33420360

about

Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase Endoplasmic reticulum stress and type 2 diabetes Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus Endoplasmic reticulum stress-sensing mechanism is activated in Entamoeba histolytica upon treatment with nitric oxide Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells Natural history of β-cell adaptation and failure in type 2 diabetes Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses β-Cell failure in type 2 diabetes.Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.Glucolipotoxicity of the pancreatic beta cell.Estimation of insulin secretion, glucose uptake by tissues, and liver handling of glucose using a mathematical model of glucose-insulin homeostasis in lean and obese mice.Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.Translational approaches: from fatty liver to non-alcoholic steatohepatitis.GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.Fatty acids suppress autophagic turnover in β-cells Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes.Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy.A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages.Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease.Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine.Regulation of pancreatic β-cell survival by nitric oxide: clinical relevance.Role of pancreatic β-cell death and inflammation in diabetes.Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy.Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes.Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes.Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition.mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines.UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.Endoplasmic reticulum stress-mediated autophagy protects against lipopolysaccharide-induced apoptosis in HL-1 cardiomyocytes.

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Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

http://www.wikidata.org/entity/Q33420360

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Glucose amplifies fatty acid-i ...... ells via activation of mTORC1.

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Glucose amplifies fatty acid-i ...... ells via activation of mTORC1.

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Glucose amplifies fatty acid-i ...... ells via activation of mTORC1.

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Glucose amplifies fatty acid-i ...... ells via activation of mTORC1.

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Erol Cerasi

http://www.w3.org/2001/XMLSchema#string

Etti Bachar

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Gil Leibowitz

http://www.w3.org/2001/XMLSchema#string

Mali Ketzinel-Gilad

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Nurit Kaiser

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Yafa Ariav

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P2860

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

Roles of CHOP/GADD153 in endoplasmic reticulum stress

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.

Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis

Signal integration in the endoplasmic reticulum unfolded protein response

TOR signaling in growth and metabolism

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Upstream and downstream of mTOR

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10.1371/JOURNAL.PONE.0004954

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3

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4

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Mali Ketzinel-Gilad

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2009-03-23T00:00:00Z

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24218888

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19305497

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endoplasmic reticulum

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2654723

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