Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.
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Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexComplex regulation of γ-secretase: from obligatory to modulatory subunitsPartial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexMitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesCharacterization of an atypical gamma-secretase complex from hematopoietic originThe mini mental state examination at the time of Alzheimer's disease and related disorders diagnosis, according to age, education, gender and place of residence: a cross-sectional study among the French National Alzheimer database.Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.Activation and intrinsic gamma-secretase activity of presenilin 1.Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 miceNot(ch) just development: Notch signalling in the adult brain.Detrimental effect of genetic inhibition of B-site APP-cleaving enzyme 1 on functional outcome after controlled cortical impact in young adult mice.Rodent models for Alzheimer's disease drug discovery.Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markersInterrelationship between changes in the amyloid β 42/40 ratio and presenilin 1 conformationDevelopment and mechanism of γ-secretase modulators for Alzheimer's disease.Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease.Pharmacological approaches for Alzheimer's disease: neurotransmitter as drug targets.Physiological and pathological roles of the γ-secretase complex.Notch in memories: Points to remember.Mechanisms of Melatonin in Alleviating Alzheimer's Disease.A TgCRND8 Mouse Model of Alzheimer's Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve.Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI.Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation.Notch in memories: Points to remember.The -980C/G polymorphism in APH-1A promoter confers risk of Alzheimer's disease.Age-related modulation of γ-secretase activity in non-human primate brains.Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
P2860
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P2860
Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@ast
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@en
type
label
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@ast
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@en
prefLabel
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@ast
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@en
P2093
P2860
P1433
P1476
Gender- and age-dependent gamm ...... in sporadic Alzheimer disease.
@en
P2093
Lisa Placanica
Yue-Ming Li
P2860
P356
10.1371/JOURNAL.PONE.0005088
P407
P577
2009-04-07T00:00:00Z