Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands
about
Next-generation antimicrobials: from chemical biology to first-in-class drugsRecent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationP6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNABrucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for BrucellosisChemical genetics of Plasmodium falciparumInhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complexIdentification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Screening a fragment cocktail library using ultrafiltration.Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in MiceThe Bacterial Sec Pathway of Protein Export: Screening and Follow-Up.Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target.Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device.Production of recombinant proteins from protozoan parasites.Target identification and validation of novel antimalarials.Use of thermal melt curves to assess the quality of enzyme preparationsOptimization of protein buffer cocktails using Thermofluor.Toxoplasma calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays.Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA).
P2860
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P2860
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Buffer optimization of thermal ...... tion of small-molecule ligands
@ast
Buffer optimization of thermal ...... tion of small-molecule ligands
@en
type
label
Buffer optimization of thermal ...... tion of small-molecule ligands
@ast
Buffer optimization of thermal ...... tion of small-molecule ligands
@en
prefLabel
Buffer optimization of thermal ...... tion of small-molecule ligands
@ast
Buffer optimization of thermal ...... tion of small-molecule ligands
@en
P2093
P2860
P356
P1476
Buffer optimization of thermal ...... tion of small-molecule ligands
@en
P2093
Alberto J Napuli
Andrew P Thomas
Christophe L M J Verlinde
Christopher J Damman
David J Leibly
Diana J Chung
Erkang Fan
Janhavi Bhandari
Kuzma V Kovzun
Lisa J Castaneda
P2860
P304
P356
10.1177/1087057109335749
P577
2009-05-21T00:00:00Z