A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors - Test2 - elhamkhani - TriplyDB

A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors

A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors

http://www.wikidata.org/entity/Q33456422

about

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus Cyclothiazide-induced persistent increase in respiratory-related activity in vitro Accessing novel conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource.The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality.A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain Natural products and ion channel pharmacology Receptor-targeting mechanisms of pain-causing toxins: How ow?The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.Conotoxin gene superfamilies.Cone snail venomics: from novel biology to novel therapeutics.Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.Emerging structural insights into the function of ionotropic glutamate receptors.Tethering toxins and peptide ligands for modulation of neuronal function High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms Recent progress in neuroactive marine natural products.Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization.How to build the fastest receptor on earth.Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework.The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.Molecular phylogeny, classification and evolution of conopeptides.Neuroscience. AMPA receptors--another twist?Pharmacology of predatory and defensive venom peptides in cone snails.

P2860

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P2860

A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors

http://www.wikidata.org/entity/Q33456422

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2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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name

A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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J.CUB.2009.05.017

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Current Biology

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A novel Conus snail polypeptid ...... ensitization of AMPA receptors

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Andres V Maricq

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Baldomero Olivera

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Craig S Walker

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David M Madsen

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John T R Isaac

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Jose A Matta

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Julita S Imperial

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Michael Ellison

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Nick Duclos

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Penelope J Brockie

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P2860

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning

A nomenclature for ligand-gated ion channels

Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

Mechanism of glutamate receptor desensitization

Structure of a glutamate-receptor ligand-binding core in complex with kainate

The glutamate receptor ion channels

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain

Mechanisms underlying presynaptic facilitatory effect of cyclothiazide at the calyx of Held of juvenile rats

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

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900-908

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