Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries.
about
Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.On-bead library screening made easier.Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.Utility of redundant combinatorial libraries in distinguishing high and low quality screening hitsThe rise, fall and reinvention of combinatorial chemistry.High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction.Process automation toward ultra-high-throughput screening of combinatorial one-bead-one-compound (OBOC) peptide libraries.Direct Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library.On-bead screens sample narrower affinity ranges of protein-ligand interactions compared to equivalent solution assays.Investigating fluorescent dyes in fluorescence-assisted screenings.Screening nonspecific interactions of peptides without background interference.Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening.Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistA liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions.Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 bindingDirect comparison of linear and macrocyclic compound libraries as a source of protein ligandsRapid lead discovery through iterative screening of one bead one compound libraries.DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library SynthesishνSABR: Photochemical Dose-Response Bead Screening in Droplets.Tumor-targeting peptides from combinatorial libraries.Asymmetric synthesis of vinylogous β-amino acids and their incorporation into mixed backbone oligomers.A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cellsSolid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides.Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging.Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
P2860
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P2860
Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Single bead labeling method fo ...... e-bead one-compound libraries.
@ast
Single bead labeling method fo ...... e-bead one-compound libraries.
@en
type
label
Single bead labeling method fo ...... e-bead one-compound libraries.
@ast
Single bead labeling method fo ...... e-bead one-compound libraries.
@en
prefLabel
Single bead labeling method fo ...... e-bead one-compound libraries.
@ast
Single bead labeling method fo ...... e-bead one-compound libraries.
@en
P2093
P1476
Single bead labeling method fo ...... e-bead one-compound libraries.
@en
P2093
Christof Buehler
Frank Kalthoff
Geraldine Garavel
Jan-Marcus Seifert
Markus Stoeckli
Martin Hintersteiner
Nicole-Claudia Meisner
Thierry Kimmerlin
Thomas Weidemann
Volker Uhl
P304
P356
10.1016/J.CHEMBIOL.2009.06.011
P50
P577
2009-07-01T00:00:00Z