Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression

Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression

Item
http://www.wikidata.org/entity/Q33528957
Identification of druggable cancer driver genes amplified across TCGA datasetsValidation of the Cancer BioChip System as a 3D siRNA screening tool for breast cancer targetsGrb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer.Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer.Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expressionContext-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.GRB7 is required for triple-negative breast cancer cell invasion and survival.Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.
P2860

Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression

Item
http://www.wikidata.org/entity/Q33528957
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@ast
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@en
Grb7 upregulation is a molecul ...... Akt-mediated gene repression.
@nl
type
label
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@ast
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@en
Grb7 upregulation is a molecul ...... Akt-mediated gene repression.
@nl
prefLabel
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@ast
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@en
Grb7 upregulation is a molecul ...... Akt-mediated gene repression.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Grb7 upregulation is a molecul ...... f Akt-mediated gene repression
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0009024
P407
P433
P478
P50
P577
P5875
P698
P932