What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?
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Rates and fitness consequences of new mutations in humansCan the experimental evolution programme help us elucidate the genetic basis of adaptation in nature?The effect of induced mutations on quantitative traits in Arabidopsis thaliana: Natural versus artificial conditionsInference of site frequency spectra from high-throughput sequence data: quantification of selection on nonsynonymous and synonymous sites in humans.Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.Evidence for widespread positive and negative selection in coding and conserved noncoding regions of Capsella grandiflora.The population genomics of a fast evolver: high levels of diversity, functional constraint, and molecular adaptation in the tunicate Ciona intestinalisAssociation between sex-biased gene expression and mutations with sex-specific phenotypic consequences in DrosophilaContributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodentsApproximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.The evolutionarily stable distribution of fitness effectsThe effects of deleterious mutations on evolution at linked sitesSystematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsA bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environmentsThe fates of mutant lineages and the distribution of fitness effects of beneficial mutations in laboratory budding yeast populationsFaster-X adaptive protein evolution in house mice.Measurements of spontaneous rates of mutations in the recent past and the near future.The fuel of evolution.Fitness effects of derived deleterious mutations in four closely related wild tomato species with spatial structure.Population Genomics of Daphnia pulex.What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?A comparison of models to infer the distribution of fitness effects of new mutations.Detecting Adaptation in Protein-Coding Genes Using a Bayesian Site-Heterogeneous Mutation-Selection Codon Substitution Model.The effects of low-impact mutations in digital organisms.Inference of purifying and positive selection in three subspecies of chimpanzees (Pan troglodytes) from exome sequencing.A Statistical Guide to the Design of Deep Mutational Scanning Experiments.An ABC method for estimating the rate and distribution of effects of beneficial mutations.Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii.The distribution of fitness effects in an uncertain world.Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data.The population genetics of mutations: good, bad and indifferent.Interaction between selection and biased gene conversion in mammalian protein-coding sequence evolution revealed by a phylogenetic covariance analysis.Pollen-specific, but not sperm-specific, genes show stronger purifying selection and higher rates of positive selection than sporophytic genes in Capsella grandiflora.Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species.Experimental determination and prediction of the fitness effects of random point mutations in the biosynthetic enzyme HisA.Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.Mutational robustness of ribosomal protein genes.New methods for inferring the distribution of fitness effects for INDELs and SNPs.Selective constraints in conserved folded RNAs of drosophilid and hominid genomes.The rate of molecular adaptation in a changing environment.
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P2860
What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?
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2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2010 թվականի ապրիլին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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What can we learn about the di ...... ations from DNA sequence data?
@ast
What can we learn about the di ...... ations from DNA sequence data?
@en
What can we learn about the di ...... ations from DNA sequence data?
@nl
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What can we learn about the di ...... ations from DNA sequence data?
@ast
What can we learn about the di ...... ations from DNA sequence data?
@en
What can we learn about the di ...... ations from DNA sequence data?
@nl
prefLabel
What can we learn about the di ...... ations from DNA sequence data?
@ast
What can we learn about the di ...... ations from DNA sequence data?
@en
What can we learn about the di ...... ations from DNA sequence data?
@nl
P2860
P356
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What can we learn about the di ...... ations from DNA sequence data?
@en
P2093
Peter D Keightley
P2860
P304
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10.1098/RSTB.2009.0266
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P577
2010-04-01T00:00:00Z