Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. - Test2 - elhamkhani - TriplyDB

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

http://www.wikidata.org/entity/Q33553780

about

Adipogenesis Linking obesity with type 2 diabetes: the role of T-bet The outliers become a stampede as immunometabolism reaches a tipping point ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses Immunological contributions to adipose tissue homeostasis Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development The role of JAK-STAT signaling in adipose tissue function.Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance.SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes.Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets Gender specificity of altered human immune cytokine profiles in aging Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity.Adipose tissue promotes a serum cytokine profile related to lower insulin sensitivity after chronic central leptin infusion Targeting senescent cells enhances adipogenesis and metabolic function in old age Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome.Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-alpha and SOCS3 Hydrodynamic tail vein injection of SOCS3 eukaryotic expression vector in vivo promoted liver lipid metabolism and hepatocyte apoptosis in mouse.Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance.Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.Fractalkine is a novel human adipochemokine associated with type 2 diabetes Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue.Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.Class II transactivator (CIITA) mediates transcriptional repression of pdk4 gene by interacting with hypermethylated in cancer 1 (HIC1)Comparative Analyses between Skeletal Muscle miRNAomes from Large White and Min Pigs Revealed MicroRNAs Associated with Postnatal Muscle Hypertrophy.Natural killer T cells in adipose tissue prevent insulin resistance Expression of Calgranulin Genes S100A8, S100A9 and S100A12 Is Modulated by n-3 PUFA during Inflammation in Adipose Tissue and Mononuclear Cells Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice Differential effects of leptin on adiponectin expression with weight gain versus obesity.Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation

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P2860

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

http://www.wikidata.org/entity/Q33553780

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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Elise H Chiquoine

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Emer M Smyth

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Roy J Kim

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P2860

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

Obesity and insulin resistance

Obesity is associated with macrophage accumulation in adipose tissue

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

The IFN gamma receptor: a paradigm for cytokine receptor signaling

Regulation of interferon-gamma during innate and adaptive immune responses

Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

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284

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Muredach P. Reilly

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