Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

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http://www.wikidata.org/entity/Q33571668

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Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1 CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis.Stabilizing rescued surface-localized δf508 CFTR by potentiation of its interaction with Na(+)/H(+) exchanger regulatory factor 1.Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator Correction of defective CFTR/ENaC function and tightness of cystic fibrosis airway epithelium by amniotic mesenchymal stromal (stem) cells.Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.Functional Rescue of F508del-CFTR Using Small Molecule Correctors Repairing the basic defect in cystic fibrosis - one approach is not enough.From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking.New Trends in Cancer Therapy: Targeting Ion Channels and Transporters.Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1.NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function.Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis.A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.MED1101: a new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells.Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics.Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells.Assembly and Functional Analysis of an S/MAR Based Episome with the Cystic Fibrosis Transmembrane Conductance Regulator Gene.Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Molecular basis of cystic fibrosis: from bench to bedside Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer

P2860

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P2860

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

Item

http://www.wikidata.org/entity/Q33571668

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@ast

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@en

Na+/H+ exchanger regulatory fa ...... n human airway CFBE41o- cells.

@nl

type

Item

label

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@ast

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@en

Na+/H+ exchanger regulatory fa ...... n human airway CFBE41o- cells.

@nl

prefLabel

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@ast

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@en

Na+/H+ exchanger regulatory fa ...... n human airway CFBE41o- cells.

@nl

P1476

Na+/H+ exchanger regulatory fa ...... in human airway CFBE41o- cells

@en

P2093

Francesca Di Sole

http://www.w3.org/2001/XMLSchema#string

Maria Favia

http://www.w3.org/2001/XMLSchema#string

Mingmin Chen

http://www.w3.org/2001/XMLSchema#string

Rosa Angela Cardone

http://www.w3.org/2001/XMLSchema#string

Stefania Monterisi

http://www.w3.org/2001/XMLSchema#string

Teresa Fanelli

http://www.w3.org/2001/XMLSchema#string

Ursula Seidler

http://www.w3.org/2001/XMLSchema#string

P2860

A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression

Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50

Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

P304

73-86

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1091/MBC.E09-03-0185

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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P577

2009-11-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19889841

http://www.w3.org/2001/XMLSchema#string

P921

cytoskeleton

cystic fibrosis

transmembrane protein

overexpression

P932

2801722

http://www.w3.org/2001/XMLSchema#string

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

about

P2860

P2860

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

description

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type

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P1433

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P1433

P1476

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P433

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P932