High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.
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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseAutophagy in the physiology and pathology of the central nervous systemLysosomal storage diseases and the heat shock response: convergences and therapeutic opportunitiesExcess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B LymphocytesEmerging roles for lipids in non-apoptotic cell deathThe pleiotropic roles of sphingolipid signaling in autophagyLysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa.Autophagy in the light of sphingolipid metabolismβ-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease.Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's diseaseLack of Acid Sphingomyelinase Induces Age-Related Retinal DegenerationCeramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.Metabolomic profiling of ascending thoracic aortic aneurysms and dissections - Implications for pathophysiology and biomarker discoveryLysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy.Host sphingomyelin increases West Nile virus infection in vivoGenetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis.Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin.The emerging role of acid sphingomyelinase in autophagy.Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids.Role of sphingomyelinases in neurological disorders.Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease.Lysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives.Lysosome and endoplasmic reticulum quality control pathways in Niemann-Pick type C disease.Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells.Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity.Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease.Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
P2860
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P2860
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.
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2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2014 թվականի հունվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@ast
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@en
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@nl
type
label
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@ast
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@en
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@nl
prefLabel
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@ast
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@en
High sphingomyelin levels indu ...... n Niemann Pick disease type A.
@nl
P2093
P2860
P356
P1476
High sphingomyelin levels indu ...... in Niemann Pick disease type A
@en
P2093
M D Ledesma
V Labrador
P2860
P2888
P304
P356
10.1038/CDD.2014.4
P577
2014-01-31T00:00:00Z