Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability - Test2 - elhamkhani - TriplyDB

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

http://www.wikidata.org/entity/Q33595674

about

C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response Roles of RNA-Binding Proteins in DNA Damage Response The RNA Splicing Response to DNA Damage BRCA1, a 'complex' protein involved in the maintenance of genomic stability Defective control of pre-messenger RNA splicing in human disease Serial interactome capture of the human cell nucleus Detained introns are a novel, widespread class of post-transcriptionally spliced introns.BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells Deciphering the BRCA1 Tumor Suppressor Network.A BRCA1-interacting lncRNA regulates homologous recombination.The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence.RNA splicing factors as oncoproteins and tumour suppressors.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.The molecular pathogenesis of the myelodysplastic syndromes.The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability.Chronic lymphocytic leukemia: Time to go past genomics?RNA Processing and Genome Stability: Cause and Consequence.Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control.Benchmarking pathway interaction network for colorectal cancer to identify dysregulated pathways.R Loops and Links to Human Disease.Splicing factor gene mutations in hematologic malignancies.The emerging role of RNAs in DNA damage repair.RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing.A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function.The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors.Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.The role of alternative splicing in cancer.The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.The impact of SF3B1 mutations in CLL on the DNA-damage response.miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.PRPF8 is important for BRCA1-mediated homologous recombination.The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage.

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Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

http://www.wikidata.org/entity/Q33595674

description

2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Identification of a BRCA1-mRNA ...... intenance of genomic stability

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Dennis J McCance

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Eliana M Barros

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Gareth W Irwin

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Julia J Gorski

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Kienan I Savage

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Manuel Salto-Tellez

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Natalia Lukashchuk

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W Glenn McCluggage

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P2860

Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Regulation of cyclin D1 RNA stability by SNIP1

NCBI GEO: archive for functional genomics data sets--update

Mutational processes molding the genomes of 21 breast cancers

The Catalogue of Somatic Mutations in Cancer (COSMIC)

Redistribution of BRCA1 among four different protein complexes following replication blockage

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

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Andrea Pellagatti

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