De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.
about
New horizons for host defense peptides and lantibioticsPeptidomimetics as a new generation of antimicrobial agents: current progressAntibacterial drug leads targeting isoprenoid biosynthesisAchievements and challenges in structural bioinformatics and computational biophysicsAntimicrobial Polymers in the Nano-WorldAntibiotics in the clinical pipeline at the end of 2015.Toward an improved structural model of the frog-skin antimicrobial peptide esculentin-1b(1-18).Functionally Diverse Nylon-3 Copolymers from Readily Accessible β-Lactams.Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedronOrientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.Molecular basis for nanoscopic membrane curvature generation from quantum mechanical models and synthetic transporter sequences.Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanismInteraction between lipids and antimicrobial oligomers studied by solid-state NMR.Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16.Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural DiversitiesC-terminal functionalization of nylon-3 polymers: effects of C-terminal groups on antibacterial and hemolytic activitiesSpecific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasisRole of cationic group structure in membrane binding and disruption by amphiphilic copolymersTargeting bacteria via iminoboronate chemistry of amine-presenting lipids.Enhanced amphiphilic profile of a short β-stranded peptide improves its antimicrobial activity."Click" immobilization on alkylated silicon substrates: model for the study of surface bound antimicrobial peptides.Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides.Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers.Accelerating membrane insertion of peripheral proteins with a novel membrane mimetic model.Polymeric drugs: Advances in the development of pharmacologically active polymers.CHARMM-GUI HMMM Builder for Membrane Simulations with the Highly Mobile Membrane-Mimetic ModelSynthesis and characterization of the 47-residue heterodimeric antimicrobial peptide distinctin, featuring directed disulfide bridge formationNylon-3 polymers with selective antifungal activityIdentification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.Toward Hemocompatible Self-assembling Antimicrobial Nanofibers: Understanding the Synergistic Effect of Supramolecular Structure and PEGylation on Hemocompatibility.Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activitiesMembrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design.Helical 1:1 α/Sulfono-γ-AA Heterogeneous Peptides with Antibacterial Activity.Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold.Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering.Antimicrobial polymers: mechanism of action, factors of activity, and applications.Recent synthetic transport systems.Killer peptide: a novel paradigm of antimicrobial, antiviral and immunomodulatory auto-delivering drugs.Recent development of small antimicrobial peptidomimetics.
P2860
Q26997072-00355428-7B7E-405E-8065-702C631CBEBFQ27026959-7F91AD5A-5C9F-4E35-A74F-C97B45530995Q27675524-01FEDC18-0D6C-44F0-908F-08E1BB6FD4C3Q28649519-943D9243-62D8-42A9-B667-69878FA2EFA9Q29248330-BB6D3DD8-BA36-47B9-8349-C59B35C7352FQ30249262-E6CEA69B-BC2F-4B22-9BB9-61AB0531C191Q30557963-72C05009-0302-43AF-BDEC-92B652E10B32Q30586419-2A031869-F8D3-4A68-A63F-BDE91D11560CQ33581261-D4EAAA38-A657-4A79-844B-9371FE9A4E73Q33599984-E1C24F6A-F0EE-4F7D-B60E-045CBE56D414Q33677435-CB8F6255-A76B-4C6D-994F-211C94549AC5Q33849225-E157199A-C5CD-4CBE-B889-6AE1C1556B14Q33911544-4246DD8D-2B6B-4FA9-8D46-6C8E100FE2E3Q34057457-02776FD7-80B9-45D7-99C2-E398A3219891Q34098551-0979B7FE-1406-4BE1-8CF4-1CF1228DB493Q34100665-E604103D-2B47-4A3E-825F-1A19F0011ACFQ34402886-15D565E3-F317-46C5-AB67-592A14D5AEC6Q34416327-9DC231D4-592E-4900-8050-0EE0EEECC54FQ34490949-A5991808-17A6-4FE0-AE7C-29C657A2D724Q35186346-CD212A85-DF28-4931-BE83-C7843AB6A228Q35548618-E88EA2A1-CED3-4BDA-8B38-9DDD2A0F8BACQ35669672-13AFAAB3-E5A5-4E56-A0D1-307E5A41DA14Q35781198-672EE325-8E7D-4DE7-A048-542E85F6DEEAQ35877407-C3838635-D419-4B3E-987B-3C8DD0F57EB1Q35926185-F440BD9F-7452-4236-8096-527002EE9B89Q36307604-932D565C-A1F5-4A93-A0E4-3952685A03D5Q36309757-C70F9968-34CB-42FC-968A-745AA409EFC7Q36551845-B52B3A09-5A58-44A6-9C02-492E5D0D9986Q36933390-9041EA89-E712-42E3-B642-6797142A6D1BQ37103558-5FCDD432-BC6C-43F9-8E68-6812E5DD4B8FQ37351341-0BCD52E8-FB36-4C4D-9107-64D71B997DDDQ37554509-7D19AD1A-7A06-4D78-A6A8-5E48553C8913Q37639825-9C4B09B2-7AED-4699-AAB3-A75884EAB0CCQ37684752-D47C06E6-ED35-4686-957E-D71FFDF30F60Q37692425-ED66FDD6-9837-4C29-AB52-8DB346C04EE0Q37724182-B5C704C7-ACC4-4887-8239-B22EE1285893Q37800814-86947822-225B-498F-8B21-77AA57976534Q37851364-3AB6D30A-C167-4AB3-8ABC-AD1CFB4F3410Q37909413-E1D6A8C8-0EFF-4BD0-8E17-B5A28C1D3EAFQ38050179-AC773C8E-1683-49A9-A3B1-436733622050
P2860
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
De novo design of antimicrobia ...... ery to practical applications.
@ast
De novo design of antimicrobia ...... ery to practical applications.
@en
type
label
De novo design of antimicrobia ...... ery to practical applications.
@ast
De novo design of antimicrobia ...... ery to practical applications.
@en
prefLabel
De novo design of antimicrobia ...... ery to practical applications.
@ast
De novo design of antimicrobia ...... ery to practical applications.
@en
P2093
P2860
P356
P1476
De novo design of antimicrobia ...... ery to practical applications.
@en
P2093
Gregory N Tew
Michael L Klein
Richard W Scott
William F Degrado
P2860
P356
10.1021/AR900036B
P407
P577
2010-01-01T00:00:00Z