Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection
about
Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Lead optimization studies of cinnamic amide EP2 antagonistsProstanoid receptor EP2 as a therapeutic targetMacrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin.Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades.Development of second generation EP2 antagonists with high selectivityRole of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer.Prostaglandin E2 receptor subtype 2 regulation of scavenger receptor CD36 modulates microglial Aβ42 phagocytosis.Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture.EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation.Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticusExpression of prostaglandin E2 prostanoid receptor EP2 and interleukin-1β in laryngeal carcinoma - preliminary studyRadiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling.Food intake, tumor growth, and weight loss in EP2 receptor subtype knockout mice bearing PGE2-producing tumors.Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recoveryImmunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Does brain inflammation mediate pathological outcomes in epilepsy?Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to BedsideDefining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus.Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders--A Review of Structure-Activity Relationships.Inflammation in Epileptic Encephalopathies.Intracellular EP2 prostanoid receptor promotes cancer-related phenotypes in PC3 cells.Discovery of G Protein-Biased EP2 Receptor Agonists.Cyclooxygenase-2 in glioblastoma multiforme.PGE2 Promotes the Migration of Mesenchymal Stem Cells through the Activation of FAK and ERK1/2 Pathway.Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord.The effect of perioperative analgesic drugs omnopon and dexketoprofen on the functional activity of immune cells in murine model of tumor surgery.Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway.Celecoxib use and circulating oxylipins in a colon polyp prevention trial.Prostaglandin E2 Produced by Alginate-Encapsulated Mesenchymal Stromal Cells Modulates the Astrocyte Inflammatory Response.Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq.Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion.Astroglial role in the pathophysiology of status epilepticus: an overview.
P2860
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P2860
Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@ast
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@en
type
label
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@ast
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@en
prefLabel
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@ast
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@en
P2860
P1476
Prostaglandin receptor EP2 in ...... ti-cancer, and neuroprotection
@en
P2093
Jianxiong Jiang
Ray Dingledine
P2860
P304
P356
10.1016/J.TIPS.2013.05.003
P577
2013-06-21T00:00:00Z