Activated ClpP kills persisters and eradicates a chronic biofilm infection - Test2 - elhamkhani - TriplyDB

Activated ClpP kills persisters and eradicates a chronic biofilm infection

Activated ClpP kills persisters and eradicates a chronic biofilm infection

http://www.wikidata.org/entity/Q33653007

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Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways The arsenal of pathogens and antivirulence therapeutic strategies for disarming them Persisters-as elusive as ever Antimicrobial Drugs in Fighting against Antimicrobial Resistance Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity Microbial biofilm formation: a need to act Biofilms in infections of the eye Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms.Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2 Lantibiotic resistance.HipBA-promoter structures reveal the basis of heritable multidrug tolerance Novel antibody-antibiotic conjugate eliminates intracellular S. aureus Biofilms in periprosthetic orthopedic infections Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics.Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells.Biofilms and persistent wound infections in United States military trauma patients: a case-control analysis The fatty acid signaling molecule cis-2-decenoic acid increases metabolic activity and reverts persister cells to an antimicrobial-susceptible state.Staphylococcus aureus biofilms: recent developments in biofilm dispersal.Synergistic interactions of vancomycin with different antibiotics against Escherichia coli: trimethoprim and nitrofurantoin display strong synergies with vancomycin against wild-type E. coli Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy.Impacts of global transcriptional regulators on persister metabolism.Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.Genetic basis of persister tolerance to aminoglycosides in Escherichia coli.Antibiofilm Activity of the Brown Alga Halidrys siliquosa against Clinically Relevant Human Pathogens The tuberculosis drug discovery and development pipeline and emerging drug targets.Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.Targets for Combating the Evolution of Acquired Antibiotic Resistance One cannot rule them all: Are bacterial toxins-antitoxins druggable?Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth.Inhibition of stationary phase respiration impairs persister formation in E. coli.A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters

P2860

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P2860

Activated ClpP kills persisters and eradicates a chronic biofilm infection

http://www.wikidata.org/entity/Q33653007

description

2013 nî lūn-bûn

@nan

2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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J N Adkins

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K Coleman

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K Lewis

http://www.w3.org/2001/XMLSchema#string

L E Fleck

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M D LaFleur

http://www.w3.org/2001/XMLSchema#string

S N Leonard

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V M Isabella

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P2860

Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

Bacterial biofilms: a common cause of persistent infections

Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR

A flexible C-terminal linker is required for proper FtsZ assembly in vitro and cytokinetic ring formation in vivo

Persister cells

The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm.

Sticking together: building a biofilm the Bacillus subtilis way.

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10.1038/NATURE12790

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7476

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Ernesto Nakayasu

Richard D. Smith

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2013-11-13T00:00:00Z

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258523357

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1018195007

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24226776

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eradication of infectious diseases

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4031760

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